Literature DB >> 3742943

Accumulation of sorbitol in endothelial cells--a possible cause of diabetic microangiopathy.

M S Koh, K J Misch, C T Yuen, E L Rhodes.   

Abstract

Human umbilical cord endothelial cells accumulate more intracellular sorbitol in response to increased glucose concentration during in vitro incubation. This accumulation of sorbitol by endothelial cells is both concentration and time dependent. Increased concentration of sorbitol in endothelial cells may be important in the pathogenesis of diabetic associated microangiopathy.

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Year:  1986        PMID： 3742943

Source DB:  PubMed          Journal:  Diabetes Res        ISSN： 0265-5985


  3 in total

Review 1.  Endothelial cell function in diabetic microangiopathy.

Authors:  M Porta; M La Selva; P Molinatti; G M Molinatti
Journal:  Diabetologia       Date:  1987-08       Impact factor: 10.122

2.  Effect of an aldose reductase inhibitor on type IV collagen production by human endothelial cells cultured in high glucose.

Authors:  A Bakillah; A M Grigorova-Borsos; R Guillot; P Urios; M Sternberg
Journal:  Diabetologia       Date:  1996-06       Impact factor: 10.122

3.  The effect of high glucose on polyol pathway activity and myoinositol metabolism in cultured human endothelial cells.

Authors:  G C Hawthorne; K Bartlett; C S Hetherington; K G Alberti
Journal:  Diabetologia       Date:  1989-03       Impact factor: 10.122
  3 in total

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