Literature DB >> 3742734

Age- and tissue-related DNA modifications in untreated rats: detection by 32P-postlabeling assay and possible significance for spontaneous tumor induction and aging.

K Randerath, M V Reddy, R M Disher.   

Abstract

When liver, kidney, lung and heart DNA preparations of untreated Sprague-Dawley rats of different ages (3 days-10 months) were analyzed for the possible presence of covalent modifications by a 32P-postlabeling assay, characteristic tissue-specific patterns of 32P-labeled spots (termed I-spots) were observed on thin-layer chromatograms. Amounts of these DNA derivatives (termed I-compounds), which were not detected in newborn rat DNA, markedly increased with age. This novel type of DNA modification could be due to environmental (e.g. dietary) factors or to endogenous DNA-reactive metabolites and may conceivably play a role in the initiation of spontaneous cancers or other adverse health effects related to aging.

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Year:  1986        PMID： 3742734     DOI： 10.1093/carcin/7.9.1615

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  20 in total

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2.  Endogenous and exogenous factors in carcinogenesis: limits to cancer prevention.

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3.  Exposure to urban and rural air pollution: DNA and protein adducts and effect of glutathione-S-transferase genotype on adduct levels.

Authors:  P S Nielsen; H Okkels; T Sigsgaard; S Kyrtopoulos; H Autrup
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Review 4.  Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.

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5.  Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct.

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Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

6.  32P-adduct assay: short- and long-term persistence of 2-acetylaminofluorene-DNA adducts and other applications of the assay.

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8.  In situ biomonitoring of caged, juvenile Chinook salmon (Oncorhynchus tshawytscha) in the Lower Duwamish Waterway.

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9.  Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

Authors:  C G Fraga; M K Shigenaga; J W Park; P Degan; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

10.  7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection.

Authors:  J W Park; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205
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