Literature DB >> 3742230

First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist.

J Schouenborg, B H Sjölund.   

Abstract

An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.

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Year:  1986        PMID： 3742230     DOI： 10.1016/0006-8993(86)90798-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

Review 1.  Neurotransmitters in subcortical somatosensory pathways.

Authors:  J Broman
Journal:  Anat Embryol (Berl)       Date:  1994-03

2.  NMDA and AMPA receptors evoke transmitter release from noradrenergic axon terminals in the rat spinal cord.

Authors:  E Sundström; L Holmberg; F Souverbie
Journal:  Neurochem Res       Date:  1998-12       Impact factor: 3.996

3.  Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord.

Authors:  S De Biasi; A Rustioni
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

4.  Opiates distinguish spinal excitation from inhibition evoked by noxious heat stimuli in the rat: relevance to theories of analgesia.

Authors:  N C Harris; R W Ryall
Journal:  Br J Pharmacol       Date:  1988-05       Impact factor: 8.739

5.  Nitric oxide-producing islet cells modulate the release of sensory neuropeptides in the rat substantia gelatinosa.

Authors:  P Aimar; L Pasti; G Carmignoto; A Merighi
Journal:  J Neurosci       Date:  1998-12-15       Impact factor: 6.167

6.  Thermal camera as a pain monitor.

Authors:  Varlik K Erel; Heval Selman Özkan
Journal:  J Pain Res       Date:  2017-12-14       Impact factor: 3.133
  6 in total

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