Literature DB >> 3742211

Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain.

F W van Leeuwen, R Caffé, P J van der Sluis, A A Sluiter, T P van der Woude, N G Seidah, M Chrétien.   

Abstract

Vasopressin (VP) is synthesized as propressophysin, containing also neurophysin (NP) and C-terminal glycopeptide (CPP), within the hypothalamo-neurohypophyseal system (HNS). Recently, VP and NP-immunoreactive cells were demonstrated in other rat brain nuclei. Here we report CPP immunoreactivity in perikarya in these nuclei. Within the homozygous Brattleboro rat, known to be deficient in neuronal VP production, no CPP immunoreactivity was seen in these nuclei. However, intense VP and CPP immunoreactivity was present in solitary cells (52.2 +/- 3.3 per rat) and fibres within the HNS.

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Year:  1986        PMID： 3742211     DOI： 10.1016/0006-8993(86)90272-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  3 in total

1.  Age-related development of a heterozygous phenotype in solitary neurons of the homozygous Brattleboro rat.

Authors:  F van Leeuwen; E van der Beek; M Seger; P Burbach; R Ivell
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

2.  Mutant vasopressin precursor in the endoplasmic reticulum of the Brattleboro rat. Ultrastructural evidence from individual "vasopressin" cells localized with the light microscope by use of a new gold/silver method for immunostain enhancement.

Authors:  S E Guldenaar; B T Pickering
Journal:  Cell Tissue Res       Date:  1988-09       Impact factor: 5.249

3.  Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons.

Authors:  D A Evans; A A van der Kleij; M A Sonnemans; J P Burbach; F W van Leeuwen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205
  3 in total

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