Literature DB >> 3741453

Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

W Dekant, M Metzler, D Henschler.   

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Year:  1986        PMID： 3741453     DOI： 10.1016/0006-2952(86)90039-0

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


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  11 in total

1.  Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine.

Authors:  Lawrence H Lash; David A Putt; Jean C Parker
Journal:  J Toxicol Environ Health A       Date:  2006-07

2.  Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture.

Authors:  A M Saillenfait; I Langonné; J P Sabaté
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

Review 3.  Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.

Authors:  Lawrence H Lash; Weihsueh A Chiu; Kathryn Z Guyton; Ivan Rusyn
Journal:  Mutat Res Rev Mutat Res       Date:  2014 Oct-Dec       Impact factor: 5.657

4.  Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.

Authors:  J N Commandeur; P J Boogaard; G J Mulder; N P Vermeulen
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

5.  Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine.

Authors:  O Ilinskaja; S Vamvakas
Journal:  Arch Toxicol       Date:  1996       Impact factor: 5.153

6.  Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine.

Authors:  W Dekant; L H Lash; M W Anders
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

7.  Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat.

Authors:  M L Anthony; C R Beddell; J C Lindon; J K Nicholson
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

8.  Induction of unscheduled DNA synthesis and micronucleus formation in Syrian hamster embryo fibroblasts treated with cysteine S-conjugates of chlorinated hydrocarbons.

Authors:  S Vamvakas; W Dekant; D Schiffmann; D Henschler
Journal:  Cell Biol Toxicol       Date:  1988-12       Impact factor: 6.691

9.  Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene.

Authors:  D Henschler; S Vamvakas; M Lammert; W Dekant; B Kraus; B Thomas; K Ulm
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

Review 10.  Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.

Authors:  R J Bull
Journal:  Environ Health Perspect       Date:  2000-05       Impact factor: 9.031
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