Literature DB >> 3741417

Induction of interferon by transformed cells: inhibition by retinoic acid.

T K Hughes, J K Russell, J E Blalock.   

Abstract

Retinoic acid (RA) inhibited transformed mouse L-929 and human WISH cell induction of interferon alpha/beta production by nonsensitized mouse spleen cells. The RA effect was both time and dose dependent and acted in near physiologic concentrations. The results suggest that the effect is due to a modulation of a previously described transformed cell surface associated glycoprotein IFN inducer.

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Year:  1986        PMID: 3741417     DOI: 10.1016/0006-291x(86)90244-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  1 in total

1.  Immunosuppressive activity of 13-cis-retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats.

Authors:  L Massacesi; E Castigli; M Vergelli; J Olivotto; A L Abbamondi; F Sarlo; L Amaducci
Journal:  J Clin Invest       Date:  1991-10       Impact factor: 14.808

  1 in total

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