Literature DB >> 3741142

Kinetics of 2,4,6-trichlorophenol in different organs of the rat.

K Pekari, C Boudène, A Aitio.   

Abstract

The concentration of 2,4,6-trichlorophenol was measured in the blood and various other tissues of the rat after IP administration of the compound at 25 mg per kg body weight. The highest concentration, 329 +/- 117 nmol X g-1, was found in the kidney. Half-times were between 1.4 and 1.8 h in the blood, brain, fat, kidney, liver and muscle. The extent of conjugation of 2,4,6-trichlorophenol was also investigated by measuring total and free chlorophenol in the blood.

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Year:  1986        PMID： 3741142     DOI： 10.1007/bf00263956

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  9 in total

1.  The pharmacokinetics and metabolism of pentachlorophenol in rats.

Authors:  W H Braun; J D Young; G E Blau; P J Gehring
Journal:  Toxicol Appl Pharmacol       Date:  1977-08       Impact factor: 4.219

2.  2,4,5- and 2,4,6-trichlorophenols.

Authors: 
Journal:  IARC Monogr Eval Carcinog Risk Chem Hum       Date:  1979-10

3.  Excretion and tissue distribution of uniformly labeled 14 C-pentachlorophenol in rats.

Authors:  R V Larsen; L E Kirsch; S M Shaw; J E Christian; G S Born
Journal:  J Pharm Sci       Date:  1972-12       Impact factor: 3.534

4.  A simple liquid chromatographic method for the analysis of penta- and tetrachlorophenols in urine of exposed workers.

Authors:  K Pekari; A Aitio
Journal:  J Chromatogr       Date:  1982-10-08

5.  UDP glucuronosyltransferase and mixed function oxidase activity in microsomes prepared by differential centrifugation and calcium aggregation.

Authors:  A Aitio; H Vainio
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1976

6.  Metabolism of tetrachlorophenols in the rat.

Authors:  U G Ahlborg; K Larsson
Journal:  Arch Toxicol       Date:  1978-02-21       Impact factor: 5.153

7.  Neurochemical effects of peroral administration of technical pentachlorophenol.

Authors:  H Savolainen; K Pekari
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1979-01

8.  Determining pentachlorophenol in body fluids by gas chromatography after acetylation.

Authors:  L L Needham; R E Cline; S L Head; J A Liddle
Journal:  J Anal Toxicol       Date:  1981 Nov-Dec       Impact factor: 3.367

9.  Persistence of tetrachlorophenol and pentachlorophenol in exposed woodworkers.

Authors:  D A Kalman; S W Horstman
Journal:  J Toxicol Clin Toxicol       Date:  1983-06
  9 in total
  2 in total

1.  Urinary excretion of chlorinated phenols in saw-mill workers.

Authors:  K Pekari; M Luotamo; J Järvisalo; L Lindroos; A Aitio
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

Review 2.  Toxicological profile of chlorophenols and their derivatives in the environment: the public health perspective.

Authors:  Etinosa O Igbinosa; Emmanuel E Odjadjare; Vincent N Chigor; Isoken H Igbinosa; Alexander O Emoghene; Fredrick O Ekhaise; Nicholas O Igiehon; Omoruyi G Idemudia
Journal:  ScientificWorldJournal       Date:  2013-04-03
  2 in total

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