Literature DB >> 3741136

3-Methylcholanthrene-induced ethoxyresorufin O-deethylase activity in alveolar type II cells of rabbit lung.

Y Kitagawa, M Okamoto, T Sugiyama, H Kitamura, K Nakahara, Y Kawashima, T Yamano.   

Abstract

Lungs of 3-methylcholanthrene-treated rabbits and those of untreated rabbits were digested with protease, and the cells were separated into an alveolar type II cell-rich fraction and a Clara cell-rich fraction by the use of counter-flow centrifugal elutriation. Drug oxidation activities of the cell homogenate of each fraction were examined. Marked elevation of ethoxyresorufin O-deethylase activity was found mainly in the cell homogenate of the alveolar type II cell-rich fraction after 3-methylcholanthrene treatment. The activity increased 6-fold with the drug treatment. Coumarin hydroxylase activity was found mainly in the cell homogenates of the Clara cell-rich fraction of the 3-methylcholanthrene-treated and untreated rabbits. The activity increased 3.5-fold with the drug treatment.

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Year:  1986        PMID： 3741136     DOI： 10.1007/bf00263947

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  11 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.

Authors:  V Ullrich; U Frommer; P Weber
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1973-05

Review 3.  Localization of metabolic activation and deactivation systems in the lung: significance to the pulmonary toxicity of xenobiotics.

Authors:  R F Minchin; M R Boyd
Journal:  Annu Rev Pharmacol Toxicol       Date:  1983       Impact factor: 13.820

4.  Specificity of rabbit pulmonary cytochrome P-450 isozymes in the activation of several aromatic amines and aflatoxin B1.

Authors:  L G Robertson; R M Philpot; E Zeiger; C R Wolf
Journal:  Mol Pharmacol       Date:  1981-11       Impact factor: 4.436

5.  Pulmonary cytochromes P-450 from rabbits treated with 3-methylcholanthrene.

Authors:  T H Ueng; A P Alvares
Journal:  Mol Pharmacol       Date:  1982-07       Impact factor: 4.436

6.  Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-de-ethylation.

Authors:  M D Burke; R A Prough; R T Mayer
Journal:  Drug Metab Dispos       Date:  1977 Jan-Feb       Impact factor: 3.922

7.  Metabolism of 2-acetylaminofluorene in isolated rabbit pulmonary cells. Evidence for the heterogeneous distribution of monooxygenase activity in lung tissue.

Authors:  R F Minchin; M E McManus; S S Thorgeirsson; D Schwartz; M R Boyd
Journal:  Drug Metab Dispos       Date:  1985 Jul-Aug       Impact factor: 3.922

8.  Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

Authors:  Y Yasukochi; B S Masters
Journal:  J Biol Chem       Date:  1976-09-10       Impact factor: 5.157

9.  Interactions between xenobiotics that increase or decrease the levels of cytochrome P-450 isozymes in rabbit lung and liver.

Authors:  C J Serabjit-Singh; P W Albro; I G Robertson; R M Philpot
Journal:  J Biol Chem       Date:  1983-11-10       Impact factor: 5.157

10.  Induction of aryl hydrocarbon hydroxylase in primary cultures of type II alveolar lung cells and binding of metabolically activated benzo[a]pyrene to nuclear macromolecules.

Authors:  R W Teel
Journal:  Cancer Lett       Date:  1979-10       Impact factor: 8.679
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  1 in total

1.  Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats.

Authors:  E Elovaara; H Vainio; A Aitio
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153
  1 in total

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