Literature DB >> 373818

Genetic control of F cells in human adults.

M A Zago, W G Wood, J B Clegg, D J Weatherall, M O'Sullivan, H Gunson.   

Abstract

Hb F levels were determined on samples from 750 normal blood donors. Six individuals (0.8%) had Hb F levels in excess of 1.1%, the upper end of the continuous distribution. Eight individuals at the upper end and 7 individuals at the lower end of the range were selected for family studies. These studies revealed that the control of Hb F levels in adults, as judged by the more sensitive F-cell technique, has a major genetic component. Structural analysis of the Hb F in several cases demonstrated that both G gamma and A gamma chains were present, but in variable proportions. These results are discussed in light of current concepts of adult F-cell production.

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Year:  1979        PMID： 373818

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  15 in total

1.  Evidence of genetic interaction between the beta-globin complex and chromosome 8q in the expression of fetal hemoglobin.

Authors:  Chad P Garner; Thanusak Tatu; Steve Best; Lisa Creary; Swee Lay Thein
Journal:  Am J Hum Genet       Date:  2002-01-30       Impact factor: 11.025

Review 2.  Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.

Authors:  Swee Lay Thein; Stephan Menzel; Mark Lathrop; Chad Garner
Journal:  Hum Mol Genet       Date:  2009-10-15       Impact factor: 6.150

3.  Detection of a major gene for heterocellular hereditary persistence of fetal hemoglobin after accounting for genetic modifiers.

Authors:  S L Thein; M Sampietro; K Rohde; J Rochette; D J Weatherall; G M Lathrop; F Demenais
Journal:  Am J Hum Genet       Date:  1994-02       Impact factor: 11.025

4.  Haplotype mapping of a major quantitative-trait locus for fetal hemoglobin production, on chromosome 6q23.

Authors:  C Garner; J Mitchell; T Hatzis; J Reittie; M Farrall; S L Thein
Journal:  Am J Hum Genet       Date:  1998-06       Impact factor: 11.025

5.  Heterocellular hereditary persistence of fetal hemoglobin (HPFH). Molecular mechanisms of abnormal gamma-gene expression in association with beta thalassemia and linkage relationship with the beta-globin gene cluster.

Authors:  A Giampaolo; F Mavilio; N M Sposi; A Carè; A Massa; L Cianetti; M Petrini; R Russo; M D Cappellini; M Marinucci
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

Review 6.  Developmental genetics of the human haemoglobins.

Authors:  W G Wood; D J Weatherall
Journal:  Biochem J       Date:  1983-10-01       Impact factor: 3.857

7.  Fetal hemoglobin accumulation in vitro. Effect of adherent mononuclear cells.

Authors:  J Javid; P K Pettis
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

8.  Magnitude of the fetal hemoglobin response to acute hemolytic anemia in baboons is controlled by genetic factors.

Authors:  J DeSimone; P Heller; J Amsel; M Usman
Journal:  J Clin Invest       Date:  1980-01       Impact factor: 14.808

9.  Fetal Hemoglobin in Tunisian Sickle Cell Disease Patient: Relationship with Polymorphic Sequences Cis to the β-Globin Gene.

Authors:  Imen Moumni; Maha Ben Mustapha; Ikbel Ben Mansour; Amine Zoraï; Kaïs Douzi; Sarah Sassi; Dorra Chaouachi; Fethi Mellouli; Mohamed Bejaoui; Salem Abbes
Journal:  Indian J Hematol Blood Transfus       Date:  2015-01-23       Impact factor: 0.900

10.  Genetic regulation of gamma gene expression: study of the interaction of beta-thalassemia with heterocellular HPFH.

Authors:  A M Soummer; U Testa; P Dujardin; A Guerrasio; A Henri; M Gazaix; J Riou; H Rochant; Y Beuzard; J Rosa
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132
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