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Literature DB >> 3734822

Motor and cognitive performances of parkinsonian patients in the on and off phases of the disease.

F Girotti, F Carella, M P Grassi, P Soliveri, R Marano, T Caraceni.

Abstract

Twenty-one Parkinsonian patients were tested in on and off phases during chronic levodopa therapy for cognitive function, affective status, and evaluation of motor performance with reaction and movement times. A worsening of mood was observed from the on to the off phase. No variation in cognitive performance was observed from the on to the off phase in spite of evident motor changes. Mood changes during on-off variations may reflect involvement of mesocortical and mesolimbic dopaminergic systems.

Entities: Chemical Disease Species

Mesh：

Substances：
Levodopa

Year: 1986 PMID： 3734822 PMCID： PMC1028847 DOI： 10.1136/jnnp.49.6.657

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

24 in total

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18 in total

1. The effect of withdrawal of dopaminergic medication on simple and choice reaction time and the use of advance information in Parkinson's disease.

Authors: M Jahanshahi; R G Brown; C D Marsden
Journal: J Neurol Neurosurg Psychiatry Date: 1992-12 Impact factor: 10.154

Motor and cognitive performances of parkinsonian patients in the on and off phases of the disease.

1. Judgment of the visual vertical and horizontal in patients with Parkinsonism.

2. Dementia in Parkinson's disease.

3. A quantitative evaluation of the effects of L-dopa on Parkinson's disease.

4. The Set test as an aid to the detection of dementia in old people.

Review 5. Tardive dyskinesia.

6. Visuospatial judgment. A clinical test.

7. Reaction times in Parkinson disease.

8. Major psychiatric disorders. A four-dimensional model.

9. Human ballistic arm abduction movements: effects of L-dopa treatment in Parkinson's disease.

10. High speed memory scanning in parkinsonism.

1. The effect of withdrawal of dopaminergic medication on simple and choice reaction time and the use of advance information in Parkinson's disease.

2. Relations between on-off phenomena and cognitive functions in Parkinson disease.

Review 3. Deterioration of dopaminergic pathways and alterations in cognition and motor functions.

4. Cognitive functioning after pallidotomy for refractory Parkinson's disease.

Review 5. Neuropsychological aspects of Parkinson's disease.

6. Evoked potentials, reaction time and cognitive performance in on and off phases of Parkinson's disease.

7. Abnormal refractoriness in patients with Parkinson's disease after brief withdrawal of levodopa treatment.

8. Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?

9. The relationship between visuospatial ability and perceptual motor function in Parkinson's disease.

10. Cognitive concomitants of dopamine system stimulation in parkinsonian patients.