Literature DB >> 3733710

Thyroid hormone regulation of malic enzyme synthesis. Dual tissue-specific control.

B Dozin, M A Magnuson, V M Nikodem.   

Abstract

The regulatory mechanism(s) involved in the tissue-specific induction of cytosolic malic enzyme (EC 1.1.1.40) by triiodothyronine (T3) have been investigated in rat liver and heart. In these two tissues, cellular malic enzyme mRNA accumulates to different extents in response to hormonal stimulation (11-16- and 3-4-fold above the respective basal levels) (Dozin, B., Magnuson, M. A., and Nikodem, V. M. (1985) Biochemistry 24, 5581-5586). To gain further insight into this pretranslational control, nuclear in vitro run-off transcription assays were performed and correlated with the levels of malic enzyme RNA sequences in cytoplasm. The data demonstrate that the rate of transcription of the malic enzyme gene is stimulated by T3 to similar extents in liver and heart (3-4-fold above the basal activity). In liver, T3 also promotes an additional increase in cellular malic enzyme mRNA. This additional effect could be due to a tissue-specific change in the rate of degradation of cytoplasmic mRNA or to an effect on malic enzyme mRNA in the nucleus.

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Year:  1986        PMID： 3733710

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  14 in total

1.  Thyroid hormone stimulates the renal Na/H exchanger NHE3 by transcriptional activation.

Authors:  A Cano; M Baum; O W Moe
Journal:  Am J Physiol       Date:  1999-01

2.  Role of thyroid hormones in apolipoprotein A-I gene expression in rat liver.

Authors:  W Strobl; N L Gorder; Y C Lin-Lee; A M Gotto; W Patsch
Journal:  J Clin Invest       Date:  1990-03       Impact factor: 14.808

3.  Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone.

Authors:  R J Koenig; G A Brent; R L Warne; P R Larsen; D D Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

4.  Structural and functional analysis of the rat malic enzyme gene promoter.

Authors:  H Morioka; G E Tennyson; V M Nikodem
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

5.  Expression, purification and preliminary crystallographic analysis of human thyroid hormone responsive protein.

Authors:  Wenzheng Zhang; Wei Peng; Mingzhuo Zhao; Dejun Lin; Zonghao Zeng; Weihong Zhou; Mark Bartlam
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-07-26

6.  Selective upregulation of lipid metabolism in skeletal muscle of foraging juvenile king penguins: an integrative study.

Authors:  Loic Teulier; Cyril Dégletagne; Benjamin Rey; Jérémy Tornos; Céline Keime; Marc de Dinechin; Mireille Raccurt; Jean-Louis Rouanet; Damien Roussel; Claude Duchamp
Journal:  Proc Biol Sci       Date:  2012-02-22       Impact factor: 5.349

7.  Positional and temporal regulation of lipogenic gene expression in mouse liver.

Authors:  E F Cochary; Z Kikinis; K E Paulson
Journal:  Gene Expr       Date:  1993

8.  Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Authors:  Giuseppe Ferrandino; Rachel R Kaspari; Olga Spadaro; Andrea Reyna-Neyra; Rachel J Perry; Rebecca Cardone; Richard G Kibbey; Gerald I Shulman; Vishwa Deep Dixit; Nancy Carrasco
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-10       Impact factor: 11.205

9.  Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.

Authors:  R J Koenig; R L Warne; G A Brent; J W Harney; P R Larsen; D D Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

10.  Identification of direct-repeat-binding protein 1 (DRP-1), a DNA-binding protein that binds specifically to the 'malic' enzyme gene promoter direct repeat element.

Authors:  K G Ford; D P Hornby; W S al Harrasy
Journal:  Biochem J       Date:  1995-11-01       Impact factor: 3.857
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