Literature DB >> 3733592

Influence of endotoxin on the distribution of cephalosporins in rabbits.

U Ganzinger, A Haslberger, H Schiel, R Omilian-Rosso, E Schütze.   

Abstract

The concentration: time courses of six different cephalosporins were studied in serum and interstitial fluid from issue cages after intravenous injection in normal and endotoxaemic rabbits. Circulatory and metabolic changes induced by endotoxin were similar to the altered organ function observed in patients with septicaemia. A significant shift of drug fractions, increase in the volume of distribution and prolonged mean residence times were observed in this model with ceftazidime, ceftriaxone and CPW 86-363, and were the result of specific changes in the peripheral compartment. The opposite findings were observed with cefotaxime, while latamoxef and cefoperazone resulted in no changes.

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Year:  1986        PMID： 3733592     DOI： 10.1093/jac/17.6.785

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  6 in total

1.  Quantification of tissue distribution of antibiotics by kinetic hysteresis analysis.

Authors:  U Ganzinger; K Neumann
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  Intrarenal distribution of vancomycin in endotoxemic rats.

Authors:  M Ngeleka; P Auclair; D Tardif; D Beauchamp; M G Bergeron
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

3.  Granulocyte colony-stimulating factor enhances endotoxin-induced decrease in biliary excretion of the antibiotic cefoperazone in rats.

Authors:  M Nadai; I Matsuda; L Wang; A Itoh; K Naruhashi; T Nabeshima; M Asai; T Hasegawa
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

4.  Alterations in pharmacokinetics and protein binding behavior of cefazolin in endotoxemic rats.

Authors:  M Nadai; T Hasegawa; K Kato; L Wang; T Nabeshima; N Kato
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

5.  Comparative pharmacokinetics of ceftazidime in young, healthy and elderly, acutely ill males.

Authors:  B Ljungberg; I Nilsson-Ehle
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

6.  Increased oral bioavailability of ciprofloxacin in cystic fibrosis patients.

Authors:  B A Christensson; I Nilsson-Ehle; B Ljungberg; A Lindblad; A S Malmborg; L Hjelte; B Strandvik
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191
  6 in total

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