Principles of irrational drug therapy.

Drugs are extensively used in medicine when they are unlikely to produce a benefit to the patient. In most instances this does no apparent harm to the patient but sometimes (for example, the extensive use of thorotrast) the results are tragic. Even when the patient is not injured, overuse of medicines is an undesirable and money-wasting behavioral pattern. Several factors relating to the social process of drug use which encourage overprescribing are discussed and the Principles of Irrational Drug Therapy are derived. These principles are presented as negative role models for the use of medicines in developing countries.