| Literature DB >> 3732998 |
J Bernuau, A Goudeau, T Poynard, F Dubois, G Lesage, B Yvonnet, C Degott, A Bezeaud, B Rueff, J P Benhamou.
Abstract
We assessed prognostic factors in 115 patients with serologically defined fulminant hepatitis B. The diagnosis in each case was based on the finding of IgM antibody to the hepatitis B core antigen in serum. Multivariate analysis showed that factor V level (p less than 0.001), patient's age (p = 0.001), absence of detectable HBsAg by radioimmunoassay (p = 0.06) and serum alpha-fetoprotein concentration (p = 0.07) were independent predictors of survival. The survival rate in the 21 patients in whom HBsAg was not detected was 47%, which was significantly higher than the survival rate of 17% observed in the 94 HBsAg-positive patients (p = 0.006). In patients with fulminant hepatitis B, the absence of HBsAg in serum as detected by radioimmunoassay has an independent, favorable prognostic value.Entities:
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Year: 1986 PMID： 3732998 DOI： 10.1002/hep.1840060417
Source DB: PubMed Journal: Hepatology ISSN： 0270-9139 Impact factor: 17.425