Literature DB >> 373141

Bioautographic visualization of aminoacylase-1: assignment of the structural gene ACY-1 to chromosome 3 in man.

S L Naylor, T B Shows, R J Klebe.   

Abstract

A bioautographic assay was developed for the visualization of aminoacylase-1 (N-acylamino acid aminohydrolase, ACY-1; EC 3.5.1.14) after zone electrophoresis. Bioautography and species differences in electrophoretic mobility of ACY-1 made it possible to investigate the chromosome assignment of the gene for human ACY-1 using human--mouse somatic cell hybrids. Human ACY-1 segregated concordantly with beta-galactosidase-A (beta GALA; EC 3.2.1.23) but showed discordant segregation with 32 other markers representing 23 linkage groups. The beta GALA gene has been previously assigned to chromosome 3. From this evidence and confirming chromosome analyses, ACY-1 has been assigned to chromosome 3. A genetic polymorphism in the electrophoretic mobility of ACY was observed in mouse strains, demonstrating that this enzyme can be mapped in genetic crosses of Mus musculus.

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Year:  1979        PMID： 373141     DOI： 10.1007/bf01538782

Source DB:  PubMed          Journal:  Somatic Cell Genet        ISSN： 0098-0366


  9 in total

1.  Localization of the active gene of aldolase on chromosome 16, and two aldolase A pseudogenes on chromosomes 3 and 10.

Authors:  S Serero; P Maire; V C Nguyen; O Cohen-Haguenauer; M S Gross; C Jégou-Foubert; M F de Tand; A Kahn; J Frézal
Journal:  Hum Genet       Date:  1988-02       Impact factor: 4.132

2.  Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p.

Authors:  Y E Miller; J D Minna; A F Gazdar
Journal:  J Clin Invest       Date:  1989-06       Impact factor: 14.808

3.  Isolated mild intellectual disability expands the aminoacylase 1 phenotype spectrum.

Authors:  Maria G Alessandrì; Manuela Casarano; Ilaria Pezzini; Stefano Doccini; Claudia Nesti; Giovanni Cioni; Roberta Battini
Journal:  JIMD Rep       Date:  2014-07-06

4.  The human homologues of Fim1, Fim2/c-Fms, and Fim3, three retroviral integration regions involved in mouse myeloblastic leukemias, are respectively located on chromosomes 6p23, 5q33, and 3q27.

Authors:  N Van Cong; S Fichelson; M S Gross; B Sola; D Bordereaux; M F de Tand; S Guilhot; S Gisselbrecht; J Frézal; P Tambourin
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

5.  Polymorphic human somatostatin gene is located on chromosome 3.

Authors:  S L Naylor; A Y Sakaguchi; L P Shen; G I Bell; W J Rutter; T B Shows
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

6.  Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism.

Authors:  Jorn Oliver Sass; Verena Mohr; Heike Olbrich; Udo Engelke; Judit Horvath; Manfred Fliegauf; Niki Tomas Loges; Susanne Schweitzer-Krantz; Ralf Moebus; Polly Weiler; Andreas Kispert; Andrea Superti-Furga; Ron A Wevers; Heymut Omran
Journal:  Am J Hum Genet       Date:  2006-01-18       Impact factor: 11.025

7.  Electrophoretic patterns of aminoacylase-1 (ACY-1) isozymes in vertebrate cells and histochemical procedure for detecting ACY-1 activity.

Authors:  H Qavi; S Kit
Journal:  Biochem Genet       Date:  1980-08       Impact factor: 1.890

8.  Mapping of aminoacylase-1 and beta-galactosidase-A to homologous regions of human chromosome 3 and mouse chromosome 9 suggests location of additional genes.

Authors:  S L Naylor; R W Elliott; J A Brown; T B Shows
Journal:  Am J Hum Genet       Date:  1982-03       Impact factor: 11.025

9.  DNA-mediated cotransfer of unlinked mammalian cell markers into mouse L cells.

Authors:  H Warrick; N Hsiung; T B Shows; R Kucherlapati
Journal:  J Cell Biol       Date:  1980-07       Impact factor: 10.539
  9 in total

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