| Literature DB >> 3731132 |
F S Chiccarelli, J A Morrison, D B Cosulich, N A Perkinson, D N Ridge, F W Sum, K C Murdock, D L Woodward, E T Arnold.
Abstract
Two polar metabolites of mitoxantrone, a clinically active antitumor agent, have been isolated and purified from the urine of patients by sequential absorption on glass wool and C18-Sep-Pak cartridges followed by preparative high-performance liquid chromatography. Negative ion chemical ionization mass spectrometry indicated that the two metabolites are the di- and mono-carboxylic acids resulting from oxidation of the terminal hydroxyl groups of the side chain(s). Mass spectral comparison of the urinary metabolites with synthetic compounds confirmed the identification.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3731132
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701