Literature DB >> 3730622

Decreased NK activity in hairy cell leukemia (HCL): an analysis at the cellular level.

L Fontana, G De Rossi, G De Sanctis, F Ensoli, M Lopez, L Annino, F Mandelli.   

Abstract

Peripheral blood lymphocytes (PBL) of eleven patients with Hairy Cell Leukemia were studied for surface phenotype and for NK activity against the K 562 cell line (using both the standard 51Cr Release Assay and the Single Cell Cytotoxicity Assay on poly-L-lysine coated coverslips). A significant reduction in NK activity, target binding cells (TBC) and NK active cells (NKa) was detected. In some cases however, despite a very low percentage of NKa, residual NK activity was observed, suggesting an efficient recycling capacity.

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Year:  1986        PMID： 3730622     DOI： 10.1007/bf00321093

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  17 in total

1.  Severe deficiency of natural killer activity in the peripheral blood of patients with hairy cell leukemia.

Authors:  L P Ruco; A Procopio; V Maccallini; A Calogero; S Uccini; L Annino; F Mandelli; C D Baroni
Journal:  Blood       Date:  1983-06       Impact factor: 22.113

Review 2.  Natural killer cells: artifact to reality: an odyssey in biology.

Authors:  R K Oldham
Journal:  Cancer Metastasis Rev       Date:  1983       Impact factor: 9.264

3.  Surface markers of human natural killer cells as analyzed in a modified single cell cytotoxicity assay on poly-L-lysine coated cover slips.

Authors:  M Vargas-Cortes; U Hellström; P Perlmann
Journal:  J Immunol Methods       Date:  1983-08-12       Impact factor: 2.303

4.  Immunoglobulin gene rearrangements in hairy cell leukemia.

Authors:  M L Cleary; G S Wood; R Warnke; J Chao; J Sklar
Journal:  Blood       Date:  1984-07       Impact factor: 22.113

5.  Cell membrane markers in acute lymphoid leukemia in relapse.

Authors:  G De Rossi; C Guglielmi; D Pasqualetti; M Lopez; F Mandelli
Journal:  Biomedicine       Date:  1981-10

6.  T lymphocyte function in hairy cell leukaemia.

Authors:  L J Sabbe; C J Meijer; J Jansen
Journal:  Clin Exp Immunol       Date:  1980-11       Impact factor: 4.330

7.  Natural killer (HNK-1+) cells in Chediak-Higashi patients are present in normal numbers but are abnormal in function and morphology.

Authors:  T Abo; J C Roder; W Abo; M D Cooper; C M Balch
Journal:  J Clin Invest       Date:  1982-07       Impact factor: 14.808

8.  Clinical staging system for hairy-cell leukemia.

Authors:  J Jansen; J Hermans
Journal:  Blood       Date:  1982-09       Impact factor: 22.113

9.  PHA-ICC, ADCC and NK in patients with ANLL in CR: human fibroblastic interferon fails to increase NK-active cell frequency.

Authors:  L Fontana; G De Rossi; G De Sanctis; V Bottari; G Avvisati; R Perricone; F Mandelli
Journal:  Leuk Res       Date:  1984       Impact factor: 3.156

10.  Recycling and target binding capacity of human natural killer cells.

Authors:  M Ullberg; M Jondal
Journal:  J Exp Med       Date:  1981-03-01       Impact factor: 14.307
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  1 in total

1.  Surface markers and cytotoxic activities of lymphocytes in monoclonal gammopathy of undetermined significance and untreated multiple myeloma. Increased phytohemagglutinin-induced cellular cytotoxicity and inverted helper/suppressor cell ratio are features common to both diseases.

Authors:  G De Rossi; G De Sanctis; V Bottari; M Tribalto; M Lopez; M T Petrucci; L Fontana
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968
  1 in total

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