Literature DB >> 37298

The protection of primates against soman poisoning by pretreatment with pyridostigmine.

P Dirnhuber, M C French, D M Green, L Leadbeater, J A Stratton.   

Abstract

The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. The protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species.

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Year:  1979        PMID： 37298     DOI： 10.1111/j.2042-7158.1979.tb13504.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  24 in total

1.  Toxicodynamic modeling of highly toxic organophosphorus compounds.

Authors:  D M Maxwell; K M Brecht; F-C T Chang; I Koplovitz; T-M Shih; R E Sweeney
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

2.  Spontaneous and oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates.

Authors:  J P Langenberg; L P De Jong; M F Otto; H P Benschop
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

Review 3.  Acetylcholinesterase inhibition resulting from exposure to inhaled OP can be prevented by pretreatment with BChE in both macaques and minipigs.

Authors:  Yvonne Rosenberg; Ashima Saxena
Journal:  Neuropharmacology       Date:  2020-05-19       Impact factor: 5.250

Review 4.  Cholinesterases and the fine line between poison and remedy.

Authors:  Carey N Pope; Stephen Brimijoin
Journal:  Biochem Pharmacol       Date:  2018-01-31       Impact factor: 5.858

5.  Effect of pyridostigmine pretreatment, HI-6 and Toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure.

Authors:  P Walday; P Aas; T Haider; F Fonnum
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

6.  Prevention of physostigmine-induced lethality by the opioid analgesic meptazinol in the mouse.

Authors:  A Bottoncetti; A Galli
Journal:  Br J Pharmacol       Date:  1987-06       Impact factor: 8.739

7.  The oxime HGG-12 as a muscarinic acetylcholine receptor antagonist without intrinsic activity in cardiac membranes.

Authors:  C Reithmann; H J Berger; G Hilf; K Werdan
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

8.  Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes.

Authors:  Malcolm Lane; D'Arice Carter; Joseph D Pescrille; Yasco Aracava; William P Fawcett; G William Basinger; Edna F R Pereira; Edson X Albuquerque
Journal:  J Pharmacol Exp Ther       Date:  2020-08-05       Impact factor: 4.030

9.  Effectiveness of 1,2,3,4-tetrahydro-9-aminoacridine (THA) as a pretreatment drug for protection of mice from acute diisopropylfluorophosphate (DFP) intoxication.

Authors:  A Galli; F Mori
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

10.  Differential sensitivity of CNS regions to acetylcholinesterase inhibition following chronic low-dose soman treatment in the rat.

Authors:  T C Howerton; M R Murphy; S A Miller; S L Hartgraves
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530
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