Literature DB >> 3729540

Low-molecular-weight proteinase inhibitor of human epidermis inhibiting papain and trypsin activity.

I Takiuchi, H Takagi, H Goi, M Kawamura, D Higuchi.   

Abstract

A low-molecular-weight proteinase inhibitor was isolated from human epidermal extracts by means of ultrafiltration, gel filtration and ion-exchange chromatography. On polyacrylamide gel electrophoresis (PAGE), the isolated fraction exhibited a single band of activity at pH 9.4, and inhibitory activity against papain and trypsin was detected in this band. Using sodium-dodecyl-sulphate PAGE, the molecular mass of the inhibitor was estimated to be 2,200 daltons.

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Year:  1986        PMID： 3729540     DOI： 10.1007/bf00412923

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  16 in total

1.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

2.  A rapid antibacterial test for mycobacteria using a reverse T type of tube in rocked culture.

Authors:  T AOYAGI; D MIZUNO
Journal:  J Gen Microbiol       Date:  1959-04

3.  Proteolytic enzymes.

Authors:  B S HARTLEY
Journal:  Annu Rev Biochem       Date:  1960       Impact factor: 23.643

4.  Elastase and trypsin inhibitors of human skin and serum. Partial purification and characterization.

Authors:  S K Junnila; C T Jansén; V K Hopsu-Havu
Journal:  Acta Derm Venereol       Date:  1971       Impact factor: 4.437

5.  Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate.

Authors:  R T Swank; K D Munkres
Journal:  Anal Biochem       Date:  1971-02       Impact factor: 3.365

6.  Studies of the low-molecular-weight keratinase inhibitor of human epidermis.

Authors:  I Takiuchi; M Koga; H Takagi; A Wakimoto
Journal:  J Dermatol       Date:  1984-04       Impact factor: 4.005

7.  Low-molecular-weight proteinase inhibitor in human plasma inhibiting papain and trypsin activity.

Authors:  I Takiuchi; Y Sei; H Takagi; Y Sagawa
Journal:  Experientia       Date:  1984-08-15

8.  Characteristics of the human skin bradykinin-destroying enzyme.

Authors:  A Gecse; J Lonovics; E Zsilinszky; L Szekeres
Journal:  J Med       Date:  1971

9.  Further studies on a new kallikrein inhibitor in human skin--its purification and characterization.

Authors:  N Toki; T Yamura
Journal:  Arch Dermatol Res       Date:  1980       Impact factor: 3.017

10.  The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.

Authors:  A J Barrett; P M Starkey
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857
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