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Literature DB >> 3729353

Comparative pharmacokinetics of azlocillin and piperacillin in normal adults.

P A Colaizzi, R E Polk, W J Poynor, A C Raffalovich, E A Cefali, L A Beightol.

Abstract

The single-dose pharmacokinetics of azlocillin and piperacillin were compared by using a randomized, crossover design. The concentrations of azlocillin in serum were consistently higher than those of piperacillin throughout an 8-h study. The area under the time-concentration curve of azlocillin was significantly greater than that of piperacillin, and the total body clearance of azlocillin was significantly lower than that of piperacillin.

Entities: Chemical

Mesh：

Substances：
Azlocillin
Piperacillin

Year: 1986 PMID： 3729353 PMCID： PMC284187 DOI： 10.1128/AAC.29.5.938

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. High-performance liquid chromatographic determination of piperacillin in plasma.

Authors: A M Brisson; J B Fourtillan
Journal: Antimicrob Agents Chemother Date: 1982-04 Impact factor: 5.191

2. Dose dependence of piperacillin pharmacokinetics.

Authors: T Bergan; J D Williams
Journal: Chemotherapy Date: 1982 Impact factor: 2.544

Review 3. Review of the pharmacokinetics and dose dependency of azlocillin in normal subjects and patients with renal insufficiency.

Authors: T Bergan
Journal: J Antimicrob Chemother Date: 1983-05 Impact factor: 5.790

4. Antibiotics against Pseudomonas.

Authors: A P Gillett
Journal: J Antimicrob Chemother Date: 1982-02 Impact factor: 5.790

5. Comparison of the activities of the new ureidopenicillins piperacillin, mezlocillin, azlocillin, and Bay k 4999 against gram-negative organisms.

Authors: L Verbist
Journal: Antimicrob Agents Chemother Date: 1979-08 Impact factor: 5.191

Comparative pharmacokinetics of azlocillin and piperacillin in normal adults.

1. High-performance liquid chromatographic determination of piperacillin in plasma.

2. Dose dependence of piperacillin pharmacokinetics.

Review 3. Review of the pharmacokinetics and dose dependency of azlocillin in normal subjects and patients with renal insufficiency.

4. Antibiotics against Pseudomonas.

5. Comparison of the activities of the new ureidopenicillins piperacillin, mezlocillin, azlocillin, and Bay k 4999 against gram-negative organisms.

6. Pharmacokinetics of piperacillin in subjects with various degrees of renal function.

7. Pharmacokinetics of azlocillin in subjects with normal and impaired renal function.

8. Pharmacokinetics of azlocillin in healthy subjects.

Review 9. Azlocillin, mezlocillin, and piperacillin: new broad-spectrum penicillins.

10. GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity.

1. Pharmacokinetic comparison of 5 g of azlocillin every 8 h and 4 g every 6 h in healthy volunteers.

Review 2. Antibiotic pharmacokinetics in cystic fibrosis. Differences and clinical significance.

3. Scaling beta-lactam antimicrobial pharmacokinetics from early life to old age.

4. Applications of minimal physiologically-based pharmacokinetic models.