Literature DB >> 3728987

A method for the preparation of 3-ketoacyl-CoA derivatives.

C Thorpe.   

Abstract

A new method for the preparation of 3-ketoacyl-CoA thioesters (from malonylsemialdehyde to long-chain and phenylpropanoic 3-keto derivatives) is described. It utilizes the facile, thermodynamically very favorable, hydration of 2-alkynoyl-CoA thioesters by enoyl-CoA hydratase. The method is simple and avoids laborious organic syntheses or the use of multicomponent enzymatic methods.

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Year:  1986        PMID： 3728987     DOI： 10.1016/0003-2697(86)90452-5

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  5 in total

1.  Measurement of the acyl-CoA intermediates of beta-oxidation by h.p.l.c. with on-line radiochemical and photodiode-array detection. Application to the study of [U-14C]hexadecanoate oxidation by intact rat liver mitochondria.

Authors:  N J Watmough; D M Turnbull; H S Sherratt; K Bartlett
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

2.  Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion.

Authors:  P T Clayton; S Eaton; A Aynsley-Green; M Edginton; K Hussain; S Krywawych; V Datta; H E Malingre; R Berger; I E van den Berg
Journal:  J Clin Invest       Date:  2001-08       Impact factor: 14.808

3.  Impaired mitochondrial beta-oxidation in a patient with an abnormality of the respiratory chain. Studies in skeletal muscle mitochondria.

Authors:  N J Watmough; L A Bindoff; M A Birch-Machin; S Jackson; K Bartlett; C I Ragan; J Poulton; R M Gardiner; H S Sherratt; D M Turnbull
Journal:  J Clin Invest       Date:  1990-01       Impact factor: 14.808

4.  Oleate beta-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase.

Authors:  André G Ntamack; Igor V Karpichev; Stephen J Gould; Gillian M Small; Horst Schulz
Journal:  Biochim Biophys Acta       Date:  2009-05

5.  Differential diagnosis of hydroxydicarboxylic aciduria based on release of 3H2O from [9,10-3H]myristic and [9,10-3H]palmitic acids by intact cultured fibroblasts.

Authors:  S E Olpin; N J Manning; K Carpenter; B Middleton; R J Pollitt
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982
  5 in total

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