Literature DB >> 372860

Creutzfeldt-Jakob disease--alteration in ganglioside sphingosine in the brain of a patient.

Y Tamai, Y Ohtani, S Miura, Y Narita, T Iwata, H Kaiya, M Namba.   

Abstract

Gangliosides isolated from the brain of patients with Creutzfelt-Jakob (C-J) disease were analyzed. The ganglioside current was abnormally low, and the percentage distributions of individual gangliosides and the long-chain base compositions were abnormal. The C20-sphingosine contents of all the ganglioside fractions were low. Abnormalities in ganglioside long-chain bases in adult human brain have been reported previously only in patients with inherited metabolic disorders. These abnormalities in C-J disease seem to be closely related to the cause of the disease.

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Year:  1979        PMID： 372860     DOI： 10.1016/0304-3940(79)90060-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  4 in total

1.  Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.

Authors:  Lihong Zhao; Stefka Spassieva; Kenneth Gable; Sita D Gupta; Lan-Ying Shi; Jieping Wang; Jacek Bielawski; Wanda L Hicks; Mark P Krebs; Juergen Naggert; Yusuf A Hannun; Teresa M Dunn; Patsy M Nishina
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-05       Impact factor: 11.205

Review 2.  Brain pathology in Niemann Pick disease type A: insights from the acid sphingomyelinase knockout mice.

Authors:  Maria Dolores Ledesma; Alessandro Prinetti; Sandro Sonnino; Edward H Schuchman
Journal:  J Neurochem       Date:  2011-01-07       Impact factor: 5.372

Review 3.  Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders.

Authors:  Marco Piccinini; Federica Scandroglio; Simona Prioni; Barbara Buccinnà; Nicoletta Loberto; Massimo Aureli; Vanna Chigorno; Elisa Lupino; Giovanni DeMarco; Annarosa Lomartire; Maria Teresa Rinaudo; Sandro Sonnino; Alessandro Prinetti
Journal:  Mol Neurobiol       Date:  2010-02-03       Impact factor: 5.590

4.  Age-dependent and regional heterogeneity in the long-chain base of A-series gangliosides observed in the rat brain using MALDI Imaging.

Authors:  Sarah Caughlin; Shikhar Maheshwari; Nina Weishaupt; Ken K-C Yeung; David Floyd Cechetto; Shawn Narain Whitehead
Journal:  Sci Rep       Date:  2017-11-23       Impact factor: 4.379
  4 in total

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