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Literature DB >> 3727

Proline endopeptidase and exopeptidase activity in polymorphonuclear granulocytes.

Abstract

Peptidases capable of releasing proline residues from polypeptides are present in the cytoplasmic fraction of rabbit polymorphonuclear granulocytes. This was shown with peptide substrates where proline is present either at the carboxy-terminal or within the polypeptide chain. Lysosomal and plasma membrane enzymes were inactive towards such polypeptides. The proline residue was hydrolyzed at either its amino end or its carboxy end. It is noteworthy that a Pro:Pro bond was cleaved both in the pentapeptide Thr-Lys-Pro-Arg and the dipeptide Pro:Pro.

Entities: Chemical Species

Mesh：

Substances：
Proline
Tuftsin

Year: 1976 PMID： 3727 DOI： 10.1007/BF01742201

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

20 in total

1. Carboxypeptidase from yeast. Large scale preparation and the application to COOH-terminal analysis of peptides and proteins.

Authors: R Hayashi; S Moore; W H Stein
Journal: J Biol Chem Date: 1973-04-10 Impact factor: 5.157

Proline endopeptidase and exopeptidase activity in polymorphonuclear granulocytes.

1. Carboxypeptidase from yeast. Large scale preparation and the application to COOH-terminal analysis of peptides and proteins.

2. Action of yeast proteinase C on synthetic peptides and poly- ,L-amino acids.

Review 3. The physiological role of gamma-globulin.

4. The characteristics, isolation and synthesis of the phagocytosis stimulating peptide tuftsin.

5. A new phagocytosis-stimulating tetrapeptide hormone, tuftsin, and its role in disease.

6. Defective phagocytosis due to tuftsin deficiency in splenectomized subjects.

7. Chromatographic characterization and opsonic activity of bovine erythropphilic and leukophilic gamma-globulins.

8. Kinetic studies of carboxypeptidase Y. I. Kinetic parameters for the hydrolysis of synthetic substrates.

9. The effect of Tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes.

10. The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes.

Review 1. Tuftsin, Thr-Lys-Pro-Arg. Anatomy of an immunologically active peptide.

2. The extracellular metalloprotease of Serratia marcescens. 2. Comparison with trypsin and substrate specificity.

3. Bactericidal activity of tuftsin.

Review 4. Proline specific endo- and exopeptidases.