Literature DB >> 3726531

Mechanism of the rapid effect of 17 beta-estradiol on medial amygdala neurons.

J Nabekura, Y Oomura, T Minami, Y Mizuno, A Fukuda.   

Abstract

The mechanism by which sex steroids rapidly modulate the excitability of neurons was investigated by intracellular recording of neurons in rat medial amygdala brain slices. Brief hyperpolarization and increased potassium conductance were produced by 17 beta-estradiol. This effect persisted after elimination of synaptic input and after suppression of protein synthesis. Thus, 17 beta-estradiol directly changes the ionic conductance of the postsynaptic membrane of medial amygdala neurons. In addition, a greater proportion of the neurons from females than from males responded to 17 beta-estradiol.

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Year:  1986        PMID： 3726531     DOI： 10.1126/science.3726531

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  51 in total

1.  Differential effects of 17beta-estradiol and testosterone on the contractile responses of porcine coronary arteries.

Authors:  H Teoh; A Quan; S W Leung; R Y Man
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

2.  Enhanced relaxation of porcine coronary arteries after acute exposure to a physiological level of 17beta-estradiol involves non-genomic mechanisms and the cyclic AMP cascade.

Authors:  H Teoh; R Y Man
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

3.  Characterization of a membrane-associated estrogen receptor in a rat hypothalamic cell line (D12).

Authors:  Darlene C Deecher; Pamela Swiggard; Donald E Frail; Lawrence T O'Connor
Journal:  Endocrine       Date:  2003-12       Impact factor: 3.633

Review 4.  Neuronal cell cultures: a tool for investigations in developmental neurobiology.

Authors:  A Cestelli; G Savettieri; G Salemi; I Di Liegro
Journal:  Neurochem Res       Date:  1992-12       Impact factor: 3.996

Review 5.  Patterns of steroid hormone effects on electrical and molecular events in hypothalamic neurons.

Authors:  D W Pfaff
Journal:  Mol Neurobiol       Date:  1989       Impact factor: 5.590

Review 6.  Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors.

Authors:  Alan R Gintzler; Nai-Jiang Liu
Journal:  Front Neuroendocrinol       Date:  2012-10-02       Impact factor: 8.606

7.  Exogenous progesterone exacerbates running response of adolescent female mice to repeated food restriction stress by changing α4-GABAA receptor activity of hippocampal pyramidal cells.

Authors:  G S Wable; Y-W Chen; S Rashid; C Aoki
Journal:  Neuroscience       Date:  2015-09-14       Impact factor: 3.590

Review 8.  Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.

Authors:  Karyn M Frick; Jaekyoon Kim
Journal:  Horm Behav       Date:  2018-05-09       Impact factor: 3.587

Review 9.  Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology.

Authors:  Marissa I Boulware; Paul G Mermelstein
Journal:  Steroids       Date:  2008-11-25       Impact factor: 2.668

Review 10.  Neuroestrogens rapidly shape auditory circuits to support communication learning and perception: Evidence from songbirds.

Authors:  Daniel M Vahaba; Luke Remage-Healey
Journal:  Horm Behav       Date:  2018-03-30       Impact factor: 3.587
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