Literature DB >> 3724748

Mechanism of peptide chain initiation in animal cells: a reevaluation.

N K Gupta, D Chakrabarti.   

Abstract

Despite numerous reports from several laboratories, the precise mechanism of peptide chain initiation in animal cells and the roles of different factors involved in this process are not clear. The most widely accepted mechanism for peptide chain initiation is that proposed several years ago by Staehelin, Anderson, Hersey and coworkers. However, results reported from several laboratories differ significantly from the results on which the above mechanism is based. In this article, we have analyzed these different reports and their significance on the proposed mechanism of peptide chain initiation. Also, we have proposed an alternative mechanism based on the results reported from our laboratory.

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Year:  1986        PMID： 3724748     DOI： 10.1007/bf00229425

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  29 in total

1.  GTP hydrolysis during methionyl-tRNAf binding to 40 S ribosomal subunits and the site of edeine inhibition.

Authors:  O W Odon; G Kramer; A B Henderson; P Pinphanichakarn; B Hardesty
Journal:  J Biol Chem       Date:  1978-03-25       Impact factor: 5.157

2.  Protein synthesis in rabbit reticulocytes. XV. Isolation of a ribosomal protein factor (CO-EIE-1) which stimulates Met-tRNAfMet binding to EIF-1.

Authors:  A Dasgupta; A Majumdar; A D George; N K Gupta
Journal:  Biochem Biophys Res Commun       Date:  1976-08-23       Impact factor: 3.575

3.  Protein synthesis in rabbit reticulocytes XIX: EIF-2 promotes dissociation of Met-tRNAf-EIF-1-GTP complex and Met-tRNAf binding to 40S ribosomes.

Authors:  A Majumdar; R Roy; A Das; A Dasgupta; N K Gupta
Journal:  Biochem Biophys Res Commun       Date:  1977-09-09       Impact factor: 3.575

4.  Protein synthesis in rabbit reticulocytes. Purification and properties of an Mr 80,000 polypeptide (Co-eIF-2A80) with Co-eIF-2A activity.

Authors:  I Chakravarty; M K Bagchi; R Roy; A C Banerjee; N K Gupta
Journal:  J Biol Chem       Date:  1985-06-10       Impact factor: 5.157

5.  Regulation of protein synthesis initiation in eucaryotes.

Authors:  S Ochoa
Journal:  Arch Biochem Biophys       Date:  1983-06       Impact factor: 4.013

6.  The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

Authors:  R Benne; J W Hershey
Journal:  J Biol Chem       Date:  1978-05-10       Impact factor: 5.157

7.  Further studies on the mode of action of the heme-controlled translational inhibitor.

Authors:  C de Haro; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

8.  Protein synthesis in rabbit reticulocytes: mechanism of protein synthesis inhibition by heme-regulated inhibitor.

Authors:  A Das; R O Ralston; M Grace; R Roy; P Ghosh-Dastidar; H K Das; B Yaghmai; S Palmieri; N K Gupta
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

9.  New initiation factor activity required for globin mRNA translation.

Authors:  J A Grifo; S M Tahara; M A Morgan; A J Shatkin; W C Merrick
Journal:  J Biol Chem       Date:  1983-05-10       Impact factor: 5.157

10.  Mode of action of the hemin-controlled inhibitor of protein synthesis: studies with factors from rabbit reticulocytes.

Authors:  C de Haro; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205
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