Proliposomes: a novel solution to an old problem.

A procedure is described for the preparation of a dry, free-flowing granular product which, on addition of water, disperses/dissolves to form an isotonic liposomal suspension, suitable for administration either intravenously or by other routes. Various parameters have been investigated including the suitability of sorbitol and sodium chloride as carrier materials, the nature of the lipid(s) in the formulation, and the extent of lipid loading onto the carrier. These factors are shown to have a marked effect on both the dry product and the hydrated liposomes.