Myocardial pharmacodynamics of dopamine, dobutamine, amrinone and isoprenaline compared in the isolated rabbit heart.

The isolated spontaneously beating rabbit heart was used for comparing the myocardial effects of isoprenaline, dobutamine, dopamine and amrinone. Both isoprenaline and dobutamine produced a progressive concentration-dependent increase in contractility from 100% to a maximum of about 200% (pD2 7.81 and 7.01, respectively) as measured by the increase in isotonic contraction rate. The simultaneous augmentations in contraction amplitude reached maxima of about 127 and 143% (pD2 7.83 and 7.05) for each of the drugs and the heart frequency rose to 202 and 162% (pD2 7.80 and 6.63), respectively. The accompanying oxygen consumption increased from 100 to 194% (pD2 7.70) for isoprenaline and to only 177% (pD2 6.36) for dobutamine. Coronary flow rate rose to 153 and 134%, respectively. Dopamine increased the contraction rate to 181% (pD2 6.26), contraction amplitude to about 122% (pD2 6.25) and heart rate to 162% (pD2, 5.85), while oxygen consumption rose to a maximum of 202% (pD2 5.69). Coronary flow rate rose to 156%. In contrast amrinone produced an unexpected slowly progressing decrease in contraction rate and contraction amplitude to about 66% (pD2 4.45 and 4.01, respectively). Oxygen consumption increased to 159% (pD2 4.10) and coronary flow rate to 210%. The positive inotropic effect of dobutamine thus equalled that of isoprenaline but with a distinct lower concomitant increase in heart frequency and oxygen consumption which may reflect a better myocardial efficiency during the action of dobutamine.