Literature DB >> 3720837

An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure.

P Bousquet, J Feldman, D Atlas.   

Abstract

We report here that topical application of clonidine displacing substance (CDS), an endogenous brain extract, directly in the nucleus reticularis lateralis (NRL) region of anaesthetized cats regularly produced hypertension. CDS (5 units) increased the mean blood pressure by 40 +/- 8%. Pretreatment of anaesthetized rabbits with intracisternal CDS (500 units) shifted to the right the dose-response curve obtained with clonidine alone injected the same way. This brain extract might be considered as an endogenous antagonist for the hypotensive effects of clonidine at least in the NRL region.

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Year:  1986        PMID： 3720837     DOI： 10.1016/0014-2999(86)90138-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

Review 1.  Biological significance of agmatine, an endogenous ligand at imidazoline binding sites.

Authors:  W Raasch; U Schäfer; J Chun; P Dominiak
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

2.  Biochemical evidence that brainstem adrenaline-containing neurons are activated during clonidine withdrawal in the spontaneously hypertensive rat.

Authors:  L Lambás-Señas; J Atkinson; J P Fluckiger; M Sonnay; G Chamba; B Renaud
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-11       Impact factor: 3.000

3.  Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit.

Authors:  J Feldman; E Tibiriça; G Bricca; M Dontenwill; A Belcourt; P Bousquet
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

4.  Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.

Authors:  Walter Raasch; Ulrich Schäfer; Fatimunnisa Qadri; Peter Dominiak
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

5.  A circulating substance cross-reacting with antiimidazoline antibodies. Detection in serum in relation to essential hypertension.

Authors:  M Dontenwill; A Molines; A Verdun; G Bricca; S Laurent; P Bousquet
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

6.  Cardiovascular effects of agmatine, a "clonidine-displacing substance", in conscious rabbits.

Authors:  B Szabo; R Urban; N Limberger; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-03       Impact factor: 3.000

Review 7.  Historic aspects in the identification of the I1 receptor and the pharmacology of imidazolines.

Authors:  P Dominiak
Journal:  Cardiovasc Drugs Ther       Date:  1994-03       Impact factor: 3.727

8.  Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages.

Authors:  Jianshen Chai; Li Luo; Fengyan Hou; Xia Fan; Jing Yu; Wei Ma; Wangqi Tang; Xue Yang; Junyu Zhu; Wenyuan Kang; Jun Yan; Huaping Liang
Journal:  PLoS One       Date:  2016-09-29       Impact factor: 3.240
  8 in total

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