Literature DB >> 3718488

The molecular structure of a rapidly formed oligomeric adenosine tetraphosphate derivative from rat heart.

W L Hutchinson, P G Morris, J Mowbray.   

Abstract

The inability to account for large systematic variations with time in soluble adenine nucleotides in perfused rat hearts [Bates, Perrett & Mowbray (1978) Biochem. J. 176, 485-493; Mowbray, Bates & Perrett (1981) FEBS Lett. 131, 55-59; Mowbray, Perrett & Bates (1984) Int. J. Biochem. 16, 889-894] led us to show that the soluble nucleotides are in rapid equilibrium with some hitherto unrecognized trichloroacetic acid/methanol-precipitable highly phosphorylated heteropolymeric form [Mowbray, Hutchinson, Tibbs & Morris (1984) Biochem. J. 223, 627-632]. Selective digestion coupled to chromatographic analysis together with m.s. and 31P-n.m.r. spectrometry have now been used to show that the likely structure for a purified oligomer that is in specific-radioactivity equilibrium with tissue ATP is 3-phospho-[glyceroyl-gamma-triphosphoroyl-5'-adenosine-3'-3- phospho]4 glyceroyl-gamma-triphosphoroyl-5'-adenosine.

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Year:  1986        PMID： 3718488      PMCID： PMC1146617          DOI： 10.1042/bj2340623

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Detection of sugars on paper chromatograms.

Authors:  W E TREVELYAN; D P PROCTER; J S HARRISON
Journal:  Nature       Date:  1950-09-09       Impact factor: 49.962

2.  Separation of the phosphoric esters on the filter paper chromatogram.

Authors:  C S HANES; F A ISHERWOOD
Journal:  Nature       Date:  1949-12-31       Impact factor: 49.962

3.  Evidence that the coupling of histone gene expression and DNA synthesis in HeLa S3 cells is not mediated at the transscriptional level.

Authors:  G Stein; J Stein; E Shephard; W Park; I Phillips
Journal:  Biochem Biophys Res Commun       Date:  1977-07-11       Impact factor: 3.575

4.  pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

Authors:  I M Kerr; R E Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

5.  Quantitative thin-layer chromatography of ATP and the products of its degradation in meat tissue.

Authors:  G A Norman; M J Follett; D A Hector
Journal:  J Chromatogr       Date:  1974-03-13

6.  Inversely related oscillations in the contents of cyclic GMP and the total adenine nucleotides in steady-state perfused rat hearts.

Authors:  J Mowbray; D J Bates; D Perrett
Journal:  FEBS Lett       Date:  1981-08-17       Impact factor: 4.124

7.  Systematic variations in the content of the purine nucleotides in the steady-state perfused rat heart. Evidence for the existence of controlled storage and release of adenine nucleotides.

Authors:  D J Bates; D Perrett; J Mowbray
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

8.  The discovery of a rapidly metabolized polymeric tetraphosphate derivative of adenosine in perfused rat heart.

Authors:  J Mowbray; W L Hutchinson; G R Tibbs; P G Morris
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

9.  A possible adenine nucleotide storage form in normal and ischaemic rat heart.

Authors:  P S Fitt; B Korecky; N Sharma
Journal:  Biosci Rep       Date:  1985-01       Impact factor: 3.840

10.  In perfused rat hearts ischaemia promotes the reversible conversion of appreciable quantities of soluble adenine nucleotides to a stable trichloroacetic acid-precipitable form.

Authors:  W L Hutchinson; D J Bates; D Perrett; J Mowbray
Journal:  Biosci Rep       Date:  1981-11       Impact factor: 3.840
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  5 in total

1.  The characterization of a new enzyme from rat liver mitochondria, oligophosphoglyceroyl-ATP 3'-phosphodiesterase.

Authors:  B Patel; A Costi; D L Hardy; J Mowbray
Journal:  Biochem J       Date:  1991-02-15       Impact factor: 3.857

2.  The role of glutamine oxidation and the purine nucleotide cycle for adaptation of tumour energetics to the transition from the anaerobic to the aerobic state.

Authors:  Z Kovacević; D Jerance; O Brkljac
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

3.  Evidence for the presence of oligophosphoglyceroyl-ATP in rat offney.

Authors:  W L Hutchinson; P J Ratcliffe; J Mowbray
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857

4.  Purinogen is not an endogenous substrate used in endothelial cells during substrate deprivation.

Authors:  O Culic; U K Decking; E Bergschneider; J Schrader
Journal:  Biochem J       Date:  1999-03-01       Impact factor: 3.857

5.  Studies of adenosine incorporation in Langendorff rat heart and rat heart mitochondria.

Authors:  P S Fitt; N Sharma; J Attia; B Korecky
Journal:  Mol Cell Biochem       Date:  1987-11       Impact factor: 3.396
  5 in total

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