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Literature DB >> 3718483

Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate.

Abstract

The maximum rates of lactate oxidation and lipogenesis from lactate by early-neonatal brain slices were considerably greater than those for utilization of glucose and 3-hydroxybutyrate at physiological concentrations. Lactate inhibited glucose utilization, but enhanced 3-hydroxybutyrate utilization. 3-Hydroxybutyrate inhibited lactate and glucose utilization. Glucose slightly inhibited oxidation of lactate and 3-hydroxybutyrate, but scarcely enhanced lipogenesis from these substrates.

Entities: Chemical Species

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Year: 1986 PMID： 3718483 PMCID： PMC1146593 DOI： 10.1042/bj2340489

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

1. Induction processes in blood-brain transfer of ketone bodies during starvation.

Authors: A Gjedde; C Crone
Journal: Am J Physiol Date: 1975-11

2. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

Authors: D H WILLIAMSON; J MELLANBY; H A KREBS
Journal: Biochem J Date: 1962-01 Impact factor: 3.857

3. Development of mitochondrial energy metabolism in rat brain.

Authors: J M Land; R F Booth; R Berger; J B Clark
Journal: Biochem J Date: 1977-05-15 Impact factor: 3.857

4. The development of phosphopyruvate carboxylase and gluconeogenesis in neonatal rats.

Authors: P H Pearce; B J Buirchell; P K Weaver; I T Oliver
Journal: Biol Neonate Date: 1974

5. The control of postnatal hypoglycemia. Suggestions based on experimental observations in neonatal rats.

Authors: M H Cake; D Yeung; I T Oliver
Journal: Biol Neonate Date: 1971

6. Beta-hydroxybutyrate transport in rat brain: developmental and dietary modulations.

Authors: T J Moore; A P Lione; M C Sugden; D M Regen
Journal: Am J Physiol Date: 1976-03

7. Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat.

Authors: J R Girard; G S Cuendet; E B Marliss; A Kervran; M Rieutort; R Assan
Journal: J Clin Invest Date: 1973-12 Impact factor: 14.808

8. Changes during development in transport processes of the blood-brain barrier.

Authors: J E Cremer; L D Braun; W H Oldendorf
Journal: Biochim Biophys Acta Date: 1976-11-02

9. The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic data.

Authors: J E Cremer; D F Heath
Journal: Biochem J Date: 1974-09 Impact factor: 3.857

10. Glucose metabolism in the newborn rat. Temporal studies in vivo.

Authors: K Snell; D G Walker
Journal: Biochem J Date: 1973-04 Impact factor: 3.857

10 in total

1. Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics.

Authors: Tonya M Bliss; Miranda Ip; Elise Cheng; Masabumi Minami; Luc Pellerin; Pierre Magistretti; Robert M Sapolsky
Journal: J Neurosci Date: 2004-07-07 Impact factor: 6.167

Review 2. How astrocytes feed hungry neurons.

Authors: Luc Pellerin
Journal: Mol Neurobiol Date: 2005-08 Impact factor: 5.590

Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate.

1. Induction processes in blood-brain transfer of ketone bodies during starvation.

2. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

3. Development of mitochondrial energy metabolism in rat brain.

4. The development of phosphopyruvate carboxylase and gluconeogenesis in neonatal rats.

5. The control of postnatal hypoglycemia. Suggestions based on experimental observations in neonatal rats.

6. Beta-hydroxybutyrate transport in rat brain: developmental and dietary modulations.

7. Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat.

8. Changes during development in transport processes of the blood-brain barrier.

9. The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic data.

10. Glucose metabolism in the newborn rat. Temporal studies in vivo.

1. Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics.

Review 2. How astrocytes feed hungry neurons.

Review 3. Metabolic fuel utilization and pyruvate oxidation during the postnatal period.

4. Carrier-mediated L-lactate transport in brush-border membrane vesicles from rat placenta during late gestation.

5. Lactate, 3-hydroxybutyrate, and glucose as substrates for the early postnatal rat brain.

6. Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain.

7. Lipogenesis from lactate in rat neurons and astrocytes in primary culture.

Review 8. Role of monocarboxylate transporters in drug delivery to the brain.

Review 9. Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons.

Review 10. Dietary Energy Partition: The Central Role of Glucose.