Literature DB >> 3718019

Heterozygous C2 deficiency associated with angioedema, myasthenia gravis, and systemic lupus erythematosus.

J Efthimiou, D D'Cruz, P Kaplan, D Isenberg.   

Abstract

We describe a patient with myasthenia gravis, systemic lupus erythematosus, and angioedema associated with heterozygous complement factor 2 (C2) deficiency. The significance of this association is controversial, though the association of C2 deficiency with certain histocompatibility antigens suggests possible linkage to immune response genes. To our knowledge this is the first report of heterozygous C2 deficiency in association with this combination of 'autoimmune' disorders, and we discuss the aetiological implications.

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Year:  1986        PMID： 3718019      PMCID： PMC1001905          DOI： 10.1136/ard.45.5.428

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  15 in total

1.  Mixed lymphocyte culture determinants and C2 deficiency: LD-7a associated with C2 deficiency in four families.

Authors:  S M Fu; R Stern; H G Kunkel; B Dupont; J A Hansen; N K Day; R A Good; C Jersild; M Fotino
Journal:  J Exp Med       Date:  1975-08-01       Impact factor: 14.307

2.  MYASTHENIA GRAVIS AND SYSTEMIC LUPUS ERYTHEMATOSUS.

Authors:  T E MAEKELAE; R RUOSTEENOJA; O WAGER; G R WALLGREN; E J JOKINEN
Journal:  Acta Med Scand       Date:  1964-06

3.  Hereditary angioedema and "familial" lupus erythematosus in identical twin boys.

Authors:  P F Kohler; J Percy; W M Campion; C J Smyth
Journal:  Am J Med       Date:  1974-03       Impact factor: 4.965

4.  Hereditary C2 deficiency with some manifestations of systemic lupus erythematosus.

Authors:  V Agnello; M M De Bracco; H G Kunkel
Journal:  J Immunol       Date:  1972-03       Impact factor: 5.422

5.  Lupus-erythematosus-like disease in three unrelated women with hereditary angioneurotic edema.

Authors:  V H Donaldson; E V Hess; A J McAdams
Journal:  Ann Intern Med       Date:  1977-03       Impact factor: 25.391

6.  Hereditary C2 deficiency: diagnosis and HLA gene complex associations.

Authors:  D J Gibson; D Glass; C B Carpenter; P H Schur
Journal:  J Immunol       Date:  1976-04       Impact factor: 5.422

7.  Inherited deficiency of the second component of complement. Rheumatic disease associations.

Authors:  D Glass; D Raum; D Gibson; J S Stillman; P H Schur
Journal:  J Clin Invest       Date:  1976-10       Impact factor: 14.808

8.  Thymoma, myasthenia gravis, erythroblastopenic anemia and systemic lupus erythematosus in one patient.

Authors:  H L MacKechnie; A H Squires; M Platts; W Pruzanski
Journal:  Can Med Assoc J       Date:  1973-10-20       Impact factor: 8.262

9.  Immunologic injury of cultured cells infected with measles virus. I. role of IfG antibody and the alternative complement pathway.

Authors:  B S Joseph; N R Cooper; M B Oldstone
Journal:  J Exp Med       Date:  1975-04-01       Impact factor: 14.307

10.  Lysis of RNA tumor viruses by human serum: direct antibody-independent triggering of the classical complement pathway.

Authors:  N R Cooper; F C Jensen; R M Welsh; M B Oldstone
Journal:  J Exp Med       Date:  1976-10-01       Impact factor: 14.307
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