Literature DB >> 3717936

In vitro inactivation of aminoglycosides by apalcillin.

D N Wright, D C Hale, B Saxon, J M Matsen.   

Abstract

Apalcillin, at concentrations of 75, 150, 300, and 600 micrograms/ml, was combined in vitro with amikacin, gentamicin, netilmicin, or tobramycin. Incubation at 37 degrees C resulted in an apalcillin concentration-dependent and time-dependent decrease of aminoglycoside activity of up to 60%. Amikacin was the most stable and tobramycin was the least stable aminoglycoside under the conditions tested.

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Year:  1986        PMID: 3717936      PMCID: PMC176410          DOI: 10.1128/AAC.29.2.353

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  15 in total

1.  Inactivation of gentamicin by penicillins in patients with renal failure.

Authors:  F R Ervin; W E Bullock; C E Nuttall
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

2.  Laboratory and clinical conditions for gentamicin inactivation by carbenicillin.

Authors:  L J Riff; G G Jackson
Journal:  Arch Intern Med       Date:  1972-12

3.  Fluorescence polarization immunoassay. iii. an automated system for therapeutic drug determination.

Authors:  M E Jolley; S D Stroupe; K S Schwenzer; C J Wang; M Lu-Steffes; H D Hill; S R Popelka; J T Holen; D M Kelso
Journal:  Clin Chem       Date:  1981-09       Impact factor: 8.327

4.  Mall order tobramycin serum levels: low values caused by ticarcillin.

Authors:  R E Polk; B J Kline
Journal:  Am J Hosp Pharm       Date:  1980-07

5.  In-vitro inactivation of aminoglycoside antibiotics by piperacillin and carbenicillin.

Authors:  D C Hale; R Jenkins; J M Matsen
Journal:  Am J Clin Pathol       Date:  1980-09       Impact factor: 2.493

6.  Apalcillin [PC-904]: spectrum of activity and beta-lactamase hydrolysis/inhibition.

Authors:  A L Barry; R N Jones; C Thornsberry
Journal:  Diagn Microbiol Infect Dis       Date:  1985-01       Impact factor: 2.803

7.  Animal model distinguishing in vitro from in vivo carbenicillin-aminoglycoside interactions.

Authors:  J A Pieper; R A Vidal; J J Schentag
Journal:  Antimicrob Agents Chemother       Date:  1980-10       Impact factor: 5.191

8.  Effect of time and concentration upon interaction between gentamicin, tobramycin, Netilmicin, or amikacin and carbenicillin or ticarcillin.

Authors:  L K Pickering; P Gearhart
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191

9.  Gentamicin and ticarcillin in subjects with end-stage renal disease. Comparison of two assay methods and evaluation of inactivation rate.

Authors:  M E Russo; E Atkin-Thor
Journal:  Clin Nephrol       Date:  1981-04       Impact factor: 0.975

10.  Effect of concentration and time upon inactivation of tobramycin, gentamicin, netilmicin and amikacin by azlocillin, carbenicillin, mecillinam, mezlocillin and piperacillin.

Authors:  L K Pickering; I Rutherford
Journal:  J Pharmacol Exp Ther       Date:  1981-05       Impact factor: 4.030

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