Literature DB >> 3715943

Reperfusion after cerebral ischemia: influence of duration of ischemia.

N V Todd, P Picozzi, H A Crockard, R R Russell.   

Abstract

The influence of the duration of ischemia on the pattern of cerebral blood flow in recirculation was studied in anesthetised rats. Severe incomplete cerebral ischemia (mean ischemic flow = 5.8 +/- 0.4 ml/100 g/min) was produced by four-vessel occlusion and recirculation permitted after 15, 30 or 60 minutes ischemia. All three groups showed an immediate hyperemia followed by hypoperfusion. Hyperemia was maximal following 15 minutes ischemia and least pronounced following 60 minutes ischemia (p = 0.0249). Hypoperfusion started most quickly following 15 minutes ischemia and was delayed following 60 minutes ischemia (p less than 0.001). In established hypoperfusion there was no difference in flow between the three groups. The possible mechanisms of these changes in flow are discussed.

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Year:  1986        PMID： 3715943     DOI： 10.1161/01.str.17.3.460

Source DB:  PubMed          Journal:  Stroke        ISSN： 0039-2499            Impact factor:   7.914


  11 in total

1.  Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion.

Authors:  Max Nedelmann; Nouha Ritschel; Simone Doenges; Alexander C Langheinrich; Till Acker; Peter Reuter; Mesut Yeniguen; Jan Pukropski; Manfred Kaps; Clemens Mueller; Georg Bachmann; Tibo Gerriets
Journal:  J Cereb Blood Flow Metab       Date:  2010-06-09       Impact factor: 6.200

Review 2.  Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage.

Authors:  James K Liu; William T Couldwell
Journal:  Neurocrit Care       Date:  2005       Impact factor: 3.210

Review 3.  The role of microthrombi and microcirculatory factors in localization and evolution of focal cerebral ischemia.

Authors:  N Heye; C Paetzold; J Cervós-Navarro
Journal:  Neurosurg Rev       Date:  1991       Impact factor: 3.042

4.  Relationship of neuronal vulnerability and calcium binding protein immunoreactivity in ischemia.

Authors:  T F Freund; G Buzsáki; A Leon; K G Baimbridge; P Somogyi
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

Review 5.  Cerebral vascular dysregulation in the ischemic brain.

Authors:  Alexander Kunz; Costantino Iadecola
Journal:  Handb Clin Neurol       Date:  2009

Review 6.  Cerebral ischaemia and surgical practice.

Authors:  N V Todd
Journal:  Ann R Coll Surg Engl       Date:  1988-01       Impact factor: 1.891

Review 7.  Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications.

Authors:  J Marc Simard; Thomas A Kent; Mingkui Chen; Kirill V Tarasov; Volodymyr Gerzanich
Journal:  Lancet Neurol       Date:  2007-03       Impact factor: 44.182

8.  Ischemia-induced changes in the electrical activity of the hippocampus.

Authors:  G Buzsàki; T F Freund; F Bayardo; P Somogyi
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

9.  Protective effect of agmatine on a reperfusion model after transient cerebral ischemia: Temporal evolution on perfusion MR imaging and histopathologic findings.

Authors:  D J Kim; D I Kim; S K Lee; S H Suh; Y J Lee; J Kim; T S Chung; J E Lee
Journal:  AJNR Am J Neuroradiol       Date:  2006-04       Impact factor: 3.825

10.  Activation of Neuropeptide Y2 Receptor Can Inhibit Global Cerebral Ischemia-Induced Brain Injury.

Authors:  Reggie Hui-Chao Lee; Celeste Yin-Chieh Wu; Cristiane T Citadin; Alexandre Couto E Silva; Harlee E Possoit; Garrett A Clemons; Christina H Acosta; Victoria A de la Llama; Jake T Neumann; Hung Wen Lin
Journal:  Neuromolecular Med       Date:  2021-05-21       Impact factor: 4.103
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