Literature DB >> 3715904

Approximate LD50 determinations of snake venoms using eight to ten experimental animals.

J Meier, R D Theakston.   

Abstract

A method is described for the assessment of lethal toxicity of venoms using a modified LD50 assay. With this test it is possible to obtain an LD50 using only 8-10 experimental animals, instead of 30 or more. It is suggested for ethical, scientific and economic reasons that this method be tested in laboratories involved in screening of venoms for lethality and, if found satisfactory, it should replace the classical LD50 assay.

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Year:  1986        PMID： 3715904     DOI： 10.1016/0041-0101(86)90199-6

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  23 in total

1.  Local and systemic toxicity of Echis carinatus venom: neutralization by Cassia auriculata L. leaf methanol extract.

Authors:  A N Nanjaraj Urs; M Yariswamy; Vikram Joshi; K N Suvilesh; M S Sumanth; Diganta Das; A Nataraju; B S Vishwanath
Journal:  J Nat Med       Date:  2014-11-07       Impact factor: 2.343

2.  Strong myotoxic activity of Trimeresurus malabaricus venom: role of metalloproteases.

Authors:  C D Raghavendra Gowda; R Rajesh; A Nataraju; B L Dhananjaya; A R Raghupathi; T V Gowda; B K Sharath; B S Vishwanath
Journal:  Mol Cell Biochem       Date:  2006-01       Impact factor: 3.396

3.  Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution.

Authors:  R Shashidharamurthy; D K Jagadeesha; K S Girish; K Kemparaju
Journal:  Mol Cell Biochem       Date:  2002-01       Impact factor: 3.396

4.  The first gene-encoded amphibian neurotoxin.

Authors:  Dewen You; Jing Hong; Mingqiang Rong; Haining Yu; Songping Liang; Yufang Ma; Hailong Yang; Jing Wu; Donghai Lin; Ren Lai
Journal:  J Biol Chem       Date:  2009-06-17       Impact factor: 5.157

5.  Effects of chlorpromazine on the enzymatic and toxic properties of the most basic phospholipase A2 from Vipera russelli snake venom.

Authors:  A S Babu; T V Gowda
Journal:  Inflamm Res       Date:  1995-08       Impact factor: 4.575

6.  Purification, characterization and binding interactions of the Chinese-cobra (Naja naja atra) serum antitoxic protein CSAP.

Authors:  J Shao; H Shen; B Havsteen
Journal:  Biochem J       Date:  1993-07-15       Impact factor: 3.857

7.  VRCTC-310--a novel compound of purified animal toxins separates antitumor efficacy from neurotoxicity.

Authors:  R A Newman; J C Vidal; L J Viskatis; J Johnson; M A Etcheverry
Journal:  Invest New Drugs       Date:  1993 May-Aug       Impact factor: 3.850

8.  Effects of the European hornet (Vespa crabro Linnaeus 1761) crude venom on its own species.

Authors:  Jerzy Nadolski
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2013-03-18

9.  In vivo evaluation of homeostatic effects of Echis carinatus snake venom in Iran.

Authors:  Hossein Salmanizadeh; Mahdi Babaie; Hossein Zolfagharian
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2013-02-27

10.  Biochemical and biological characterization of Naja kaouthia venom from North-East India and its neutralization by polyvalent antivenom.

Authors:  Diganta Das; Nanjaraj Urs; Vilas Hiremath; Bannikuppe Sannanaik Vishwanath; Robin Doley
Journal:  J Venom Res       Date:  2013-11-06
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