Literature DB >> 3714455

DMO-transport in human red blood cells.

K F Schnell, G Michelson, C Albers.   

Abstract

The DMO (5,5-dimethyloxazolidine-2,4-dione) transport was studied in human red blood cells by measuring the 14C-DMO back exchange under self exchange conditions from 14C-DMO labeled cells at 0 degrees C. the unidirectional DMO-flux was linearly related to the DMO concentration up to approx. 100 mM. The unidirectional DMO-flux increases as pH is reduced. The DMO transport is not inhibited by anion transport inhibitors like DIDS, SITS, dipyridamole, phlorhizin, salicylate or butanol. A close correlation between the unidirectional DMO-flux and DMOH, the unionized form of DMO, has been observed suggesting that DMO is transported predominantly by nonionic diffusion. the permeability of DMOH is 9.5 X 10(-6) cm/s (0 degrees C) while the permeability of DMO- cannot be assessed from our data.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3714455     DOI： 10.1007/bf00584022

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  20 in total

1.  Chloride and water distribution in human red cells.

Authors:  M Dalmark
Journal:  J Physiol       Date:  1975-08       Impact factor: 5.182

2.  Effect of phloretin on the permeability of thin lipid membranes.

Authors:  O S Andersen; A Finkelstein; I Katz; A Cass
Journal:  J Gen Physiol       Date:  1976-06       Impact factor: 4.086

3.  Comparison of microelectrode, DMO, and methylamine methods for measuring intracellular pH.

Authors:  W F Boron; A Roos
Journal:  Am J Physiol       Date:  1976-09

Review 4.  Properties and structural basis of simple diffusion pathways in the erythrocyte membrane.

Authors:  B Deuticke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

Review 5.  Intracellular pH.

Authors:  A Roos; W F Boron
Journal:  Physiol Rev       Date:  1981-04       Impact factor: 37.312

Review 6.  Inhibition of anion permeability by amphiphilic compounds in human red cell: evidence for an interaction of niflumic acid with the band 3 protein.

Authors:  J L Cousin; R Motais
Journal:  J Membr Biol       Date:  1979-04-20       Impact factor: 1.843

7.  Calculation of intracellular pH from the distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO); application to skeletal muscle of the dog.

Authors:  W J WADDELL; T C BUTLER
Journal:  J Clin Invest       Date:  1959-05       Impact factor: 14.808

8.  Membrane permeability to the molecular and ionic forms of DMO in barnacle muscle.

Authors:  D W Keifer; A Roos
Journal:  Am J Physiol       Date:  1981-01

9.  Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties.

Authors:  B Deuticke; E Beyer; B Forst
Journal:  Biochim Biophys Acta       Date:  1982-01-04

10.  Permeability of human red cells to a homologous series of aliphatic alcohols. Limitations of the continuous flow-tube method.

Authors:  J Brahm
Journal:  J Gen Physiol       Date:  1983-02       Impact factor: 4.086
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.