Literature DB >> 3711883

Brain histamine metabolism in transmissible spongiform encephalopathy (scrapie).

J Z Nowak, A Bogucki, P Liberski.   

Abstract

The histamine (Hi) content and the activity of L-histidine decarboxylase (HD) in brains of scrapie infected hamsters were measured. No significant changes in Hi levels in particular brain areas were found when compared to controls. Decreased activity of HD was found in hypothalamus (p less than 0.02). Increased activity of the enzyme was observed in "rest of brain", which consisted mainly of thalamus and striatum (p less than 0.05).

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Year:  1986        PMID: 3711883     DOI: 10.1007/bf01249081

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  15 in total

Review 1.  Histaminergic mechanisms in brain.

Authors:  J C Schwartz
Journal:  Annu Rev Pharmacol Toxicol       Date:  1977       Impact factor: 13.820

Review 2.  Histamine as a transmitter in brain.

Authors:  J C Schwartz
Journal:  Life Sci       Date:  1975-08-15       Impact factor: 5.037

3.  Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation.

Authors:  H Fraser; A G Dickinson
Journal:  J Comp Pathol       Date:  1973-01       Impact factor: 1.311

4.  Properties and regional distribution of histidine decarboxylase in rat brain.

Authors:  J C Schwartz; C Lampart; C Rose
Journal:  J Neurochem       Date:  1970-11       Impact factor: 5.372

5.  Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway.

Authors:  H Fraser
Journal:  Nature       Date:  1982-01-14       Impact factor: 49.962

6.  Neuropathology of experimental transmissible spongiform encephalopathy (263 K strain of scrapie in golden Syrian hamsters). I. Standard pathology and development of lesions.

Authors:  P P Liberski; J Alwasiak
Journal:  Neuropatol Pol       Date:  1983

7.  Histamine in the rat brain: effect of treatment with histidine, histamine H1-, and H2-receptor antagonists and tricyclic antidepressant drugs.

Authors:  J Z Nowak; E Zandarowska
Journal:  Pol J Pharmacol Pharm       Date:  1980 Sep-Oct

8.  Serotonin concentrations in brain and blood of scrapie-infected and normal hamsters and mice.

Authors:  R G Rohwer; L M Neckers; J B Trepel; D C Gajdusek; R J Wyatt
Journal:  Brain Res       Date:  1981-09-14       Impact factor: 3.252

9.  Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker.

Authors:  T Watanabe; Y Taguchi; S Shiosaka; J Tanaka; H Kubota; Y Terano; M Tohyama; H Wada
Journal:  Brain Res       Date:  1984-03-12       Impact factor: 3.252

10.  Monoamine abnormalities in the brain of scrapie-infected rats.

Authors:  M H Bassant; D Fage; J Dedek; F Cathala; L Court; B Scatton
Journal:  Brain Res       Date:  1984-08-06       Impact factor: 3.252

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