Literature DB >> 3710864

Adriamycin resistance, heat resistance and radiation response in Chinese hamster fibroblasts.

K Wallner, G C Li.   

Abstract

We have investigated the effect of heat, radiation or Adriamycin (ADR) on Chinese hamster fibroblasts (HA-1), their heat resistant variants, and their ADR resistant variants. Heat or ADR resistance did not confer cross resistance to radiation. Cells resistant to heat did show cross resistance to ADR. Cells selected for ADR resistance were not cross resistant to heat and they did not exhibit drug potentiation by hyperthermia, characteristic of ADR sensitive cells. Cytofluorometric measurement showed decreased ADR uptake in both heat and ADR resistant cells. The possibility of cross resistance between heat and ADR should be considered when designing treatment protocols involving combined modality trials.

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Year:  1986        PMID： 3710864     DOI： 10.1016/0360-3016(86)90043-x

Source DB:  PubMed          Journal:  Int J Radiat Oncol Biol Phys        ISSN： 0360-3016            Impact factor:   7.038


  11 in total

1.  Biochemical requirements for the expression of heat shock protein 72 kda in human breast cancer MCF-7 cells.

Authors:  J G Kiang; I D Gist; G C Tsokos
Journal:  Mol Cell Biochem       Date:  1999-09       Impact factor: 3.396

Review 2.  Molecular mechanisms of drug resistance.

Authors:  J D Hayes; C R Wolf
Journal:  Biochem J       Date:  1990-12-01       Impact factor: 3.857

3.  Genistein inhibits herbimycin A-induced over-expression of inducible heat shock protein 70 kDa.

Authors:  Juliann G Kiang
Journal:  Mol Cell Biochem       Date:  2003-03       Impact factor: 3.396

Review 4.  Experimental and clinical studies alternating chemotherapy and radiotherapy.

Authors:  W B Looney; H A Hopkins; M Tubiana
Journal:  Cancer Metastasis Rev       Date:  1989-06       Impact factor: 9.264

Review 5.  Chemotherapeutic drug resistance in the management of head and neck cancer.

Authors:  H Bier
Journal:  Eur Arch Otorhinolaryngol       Date:  1993       Impact factor: 2.503

6.  Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells.

Authors:  J G Kiang; I D Gist; G C Tsokos
Journal:  Mol Cell Biochem       Date:  2000-01       Impact factor: 3.396

7.  Hyperthermic potentiation of BCNU toxicity in BCNU-resistant human glioma cells.

Authors:  V F Da Silva; M Feeley; G P Raaphorst
Journal:  J Neurooncol       Date:  1991-08       Impact factor: 4.130

Review 8.  Heat shock proteins and drug resistance.

Authors:  S A Fuqua; S Oesterreich; S G Hilsenbeck; D D Von Hoff; J Eckardt; C K Osborne
Journal:  Breast Cancer Res Treat       Date:  1994       Impact factor: 4.872

9.  New insights into the kinetic resistance to anticancer agents.

Authors:  B Chauffert; M T Dimanche-Boitrel; C Garrido; M Ivarsson; M Martin; F Martin; E Solary
Journal:  Cytotechnology       Date:  1998-09       Impact factor: 2.058

Review 10.  Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: 'What does not kill me strengthens me'.

Authors:  A O Pisco; S Huang
Journal:  Br J Cancer       Date:  2015-05-12       Impact factor: 7.640
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