Literature DB >> 3709807

Isolation and characterization of variant IGF-1 as well as IGF-2 from adult human brain.

C Carlsson-Skwirut, H Jörnvall, A Holmgren, C Andersson, T Bergman, G Lundquist, B Sjögren, V R Sara.   

Abstract

The forms of somatomedin present in the adult human brain have been characterized in this study. Two peptides were purified by acidification, size exclusion chromatography, affinity chromatography, FPLC and HPLC. Structural analysis identified these peptides as the variant form of IGF-1 with a truncated N-terminal region earlier isolated from human fetal brain and IGF-2. The presence of the truncated IGF-1 variant and IGF-2 in the human CNS suggests their role as neuropeptides.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3709807     DOI： 10.1016/0014-5793(86)80568-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue.

Authors:  E Y Adashi; C E Resnick; E Ricciarelli; A Hurwitz; E Kokia; C Tedeschi; L Botero; E R Hernandez; R G Rosenfeld; C Carlsson-Skwirut
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

Review 2.  Neurodevelopmental effects of insulin-like growth factor signaling.

Authors:  John O'Kusky; Ping Ye
Journal:  Front Neuroendocrinol       Date:  2012-06-16       Impact factor: 8.606

Review 3.  Molecular biology of the insulin-like growth factors. Relevance to nervous system function.

Authors:  J E Hepler; P K Lund
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

Review 4.  The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity.

Authors:  Anastassios Philippou; Maria Maridaki; Spiros Pneumaticos; Michael Koutsilieris
Journal:  Mol Med       Date:  2014-05-07       Impact factor: 6.354

5.  Specific binding of insulin-like growth factors 1 and 2 to the type 1 and type 2 receptors respectively.

Authors:  F J Ballard; M Ross; F M Upton; G L Francis
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

6.  Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

Authors:  F Stylianopoulou; J Herbert; M B Soares; A Efstratiadis
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

7.  A key functional role for the insulin-like growth factor 1 N-terminal pentapeptide.

Authors:  C J Bagley; B L May; L Szabo; P J McNamara; M Ross; G L Francis; F J Ballard; J C Wallace
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

8.  Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

Authors:  G K Haselbacher; J C Irminger; J Zapf; W H Ziegler; R E Humbel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

Review 9.  Insulin and insulin-like growth factor receptors in the nervous system.

Authors:  M Adamo; M K Raizada; D LeRoith
Journal:  Mol Neurobiol       Date:  1989 Spring-Summer       Impact factor: 5.590

10.  Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.

Authors:  J C Irminger; K M Rosen; R E Humbel; L Villa-Komaroff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.