Literature DB >> 37098

Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors.

P Greengrass, R Bremner.   

Abstract

3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.

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Year:  1979        PMID： 37098     DOI： 10.1016/0014-2999(79)90202-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  53 in total

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Authors:  Yesim A Tahirovic; Matthew Geballe; Ewa Gruszecka-Kowalik; Scott J Myers; Polina Lyuboslavsky; Phuong Le; Adam French; Hasan Irier; Woo-Baeg Choi; Keith Easterling; Hongjie Yuan; Lawrence J Wilson; Robert Kotloski; James O McNamara; Raymond Dingledine; Dennis C Liotta; Stephen F Traynelis; James P Snyder
Journal:  J Med Chem       Date:  2008-09-25       Impact factor: 7.446

2.  Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist.

Authors:  A Doble; D Girdlestone; O Piot; D Allam; J Betschart; A Boireau; A Dupuy; C Guérémy; J Ménager; J L Zundel
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

3.  Discovery of Quinazoline-Based Fluorescent Probes to α1-Adrenergic Receptors.

Authors:  Wei Zhang; Zhao Ma; Wenhua Li; Geng Li; Laizhong Chen; Zhenzhen Liu; Lupei Du; Minyong Li
Journal:  ACS Med Chem Lett       Date:  2015-03-30       Impact factor: 4.345

4.  Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.

Authors:  P C Waldmeier; M Williams; P A Baumann; S Bischoff; M A Sills; R F Neale
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-06       Impact factor: 3.000

5.  Immortalization of bipotential and plastic glio-neuronal precursor cells.

Authors:  C Evrard; I Borde; P Marin; E Galiana; J Prémont; F Gros; P Rouget
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

6.  Pharmacokinetic and pharmacodynamic studies with two alpha-adrenoceptor antagonists, doxazosin and prazosin in the rabbit.

Authors:  C A Hamilton; J L Reid; J Vincent
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

7.  A study of alpha 1-adrenoceptors in rat renal cortex: comparison of [3H]-prazosin binding with the alpha 1-adrenoceptor modulating gluconeogenesis under physiological conditions.

Authors:  G A McPherson; R J Summers
Journal:  Br J Pharmacol       Date:  1982-09       Impact factor: 8.739

8.  5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism.

Authors:  Zoltán Doleviczényi; E Sylvester Vizi; István Gacsályi; Katalin Pallagi; Balázs Volk; László G Hársing; György Halmos; Balázs Lendvai; Tibor Zelles
Journal:  Neurochem Res       Date:  2008-07-29       Impact factor: 3.996

9.  Prazosin selectively antagonizes neuronal responses mediated by alpha1-adrenoceptors in brain.

Authors:  D B Menkes; J M Baraban; G K Aghajanian
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-11       Impact factor: 3.000

10.  3H-WB 4101 binding in the rat vas deferens. Effects of chronic treatments with desipramine and prazosin.

Authors:  H W Wetzel; M S Briley; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-11       Impact factor: 3.000
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