Literature DB >> 3709766

The protective effect of Thiola against the genotoxic action of benzo(a)pyrene.

D Galdean, D Petrasincu, P Alangiu, S Ibric, N Voiculetz.   

Abstract

The protective effect of Thiola against the genotoxicity, induced by benzo(a)pyrene, in vitro and in vivo, was investigated. By association of Thiola to benzo(a)pyrene a significant decrease of the numerical and structural chromosome aberrations and a reduction of the incidence of c-mitoses has been obtained in human diploid cells, i.e. human embryonic lung fibroblasts of the cell-line ICP-23, and C56B1/6 mouse bone marrow cells.

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Year:  1986        PMID: 3709766     DOI: 10.1007/bf01946709

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  13 in total

1.  Enzymatic conjugation of benzo (a) pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid.

Authors:  N Nemoto; H V Gelboin
Journal:  Biochem Pharmacol       Date:  1976-05-15       Impact factor: 5.858

2.  Chromosome structure and function in man. I. Pachytene mapping in the male, improved methods and general discussion of initial results.

Authors:  D A Hungerford
Journal:  Cytogenetics       Date:  1971

3.  A study of the cytogenetics of the human cell strain WI-38.

Authors:  Z K Kadanka; J D Sparkes; H G Macmorine
Journal:  In Vitro       Date:  1973 Mar-Apr

4.  Spindle disturbances in mammalian cells. II. Induction of viable aneuploid/polyploid cells and multiple chromatid exchanges after treatment of V79 Chinese hamster cells with carbaryl. Modifying effects of glutathione and S9.

Authors:  A Onfelt; I Klasterska
Journal:  Mutat Res       Date:  1983-03       Impact factor: 2.433

Review 5.  Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

Authors:  H V Gelboin
Journal:  Physiol Rev       Date:  1980-10       Impact factor: 37.312

6.  Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes.

Authors:  J R Babson; N S Abell; D J Reed
Journal:  Biochem Pharmacol       Date:  1981-08-15       Impact factor: 5.858

7.  Modification of the teratogenicity and mutagenicity of cyclophosphamide with thiol compounds.

Authors:  B F Hales
Journal:  Teratology       Date:  1981-06

8.  Methodological model of handling a newly isolated human diploid cell strain and its surveillance.

Authors:  D E Petraşincu; N A Gaicu
Journal:  Arch Roum Pathol Exp Microbiol       Date:  1977 Jan-Mar

9.  Mechanism of the protective action of thiol compounds in ethanol-induced liver injury.

Authors:  C Hirayama; Y Kishimoto; T Wakushima; Y Murawaki
Journal:  Biochem Pharmacol       Date:  1983-01-15       Impact factor: 5.858

10.  Benzo[a]pyrene diol epoxide DNA adduct formation in transformable and non-transformable human foreskin fibroblast cells in vitro.

Authors:  R Tejwani; A M Jeffrey; G E Milo
Journal:  Carcinogenesis       Date:  1982       Impact factor: 4.944

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