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Literature DB >> 3709627

Single dose oxazepam has no effect on acetaminophen clearance or metabolism.

Abstract

The metabolism of acetaminophen and oxazepam in humans is mainly dependent on the microsomal capacity for glucuronide conjugation. The clearance of acetaminophen and the formation of metabolites were evaluated in 7 patients before and during concomitant administration of oxazepam 30 mg. The subjects received a single 500 mg dose of acetaminophen i.v. and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites. The single therapeutic dose of oxazepam had no effect on the clearance of acetaminophen or on formation of its metabolites.

Entities: Chemical Species

Mesh：

Substances：
Acetaminophen
Oxazepam

Year: 1986 PMID： 3709627 DOI： 10.1007/bf00614210

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

13 in total

1. Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.

Authors: A R Buckpitt; D E Rollins; S D Nelson; R B Franklin; J R Mitchell
Journal: Anal Biochem Date: 1977-11 Impact factor: 3.365

2. Inhibition of acetaminophen glucuronidation by oxazepam.

Authors: E Dybing
Journal: Biochem Pharmacol Date: 1976-06-15 Impact factor: 5.858

3. Drug biotransformation interactions in man. I. Mutual inhibition in glucuronide formation of salicylic acid and salicylamide in man.

Authors: G Levy; J A Procknal
Journal: J Pharm Sci Date: 1968-08 Impact factor: 3.534

4. Drug biotransformation interactions in man. 3. Acetaminophen and salicylamide.

Authors: G Levy; H Yamada
Journal: J Pharm Sci Date: 1971-02 Impact factor: 3.534

Review 5. Conjugation reactions in foreign-compound metabolism: definition, consequences, and species variations.

Authors: J Caldwell
Journal: Drug Metab Rev Date: 1982 Impact factor: 4.518

6. Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases.

Authors: J B Watkins; Z Gregus; T N Thompson; C D Klaassen
Journal: Toxicol Appl Pharmacol Date: 1982-07 Impact factor: 4.219

7. Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.

Authors: P Moldéus
Journal: Biochem Pharmacol Date: 1978 Impact factor: 5.858

8. Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.

Authors: H E Poulsen; A Lerche; N T Pedersen
Journal: Pharmacology Date: 1985 Impact factor: 2.547

9. Dual role of glucuronyl- and sulfotransferases converting xenobiotics into reactive or biologically inactive and easily excretable compounds.

Authors: K W Bock
Journal: Arch Toxicol Date: 1977-12-30 Impact factor: 5.153

Single dose oxazepam has no effect on acetaminophen clearance or metabolism.

1. Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.

2. Inhibition of acetaminophen glucuronidation by oxazepam.

3. Drug biotransformation interactions in man. I. Mutual inhibition in glucuronide formation of salicylic acid and salicylamide in man.

4. Drug biotransformation interactions in man. 3. Acetaminophen and salicylamide.

Review 5. Conjugation reactions in foreign-compound metabolism: definition, consequences, and species variations.

6. Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases.

7. Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.

8. Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.

9. Dual role of glucuronyl- and sulfotransferases converting xenobiotics into reactive or biologically inactive and easily excretable compounds.

Review 10. Kinetics and metabolism of paracetamol and phenacetin.

1. Single dose primaquine has no effect on paracetamol clearance.

2. Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism.

3. Concomitant overdosing of other drugs in patients with paracetamol poisoning.

4. Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism.