Literature DB >> 3709622

Serum level, half-life and apparent volume of distribution of doxycycline in geriatric patients.

R Böcker, W Mühlberg, D Platt, C J Estler.   

Abstract

The serum level, half-life and apparent volume of distribution of doxycycline were determined in geriatric patients. The serum level and apparent volume of distribution were higher than those reported for younger persons. The apparent volume of distribution was correlated with the serum iron and beta-globulin levels. The possible influence of binding of doxycycline to serum iron on its pharmacokinetics is discussed.

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Year:  1986        PMID： 3709622     DOI： 10.1007/bf00614205

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  12 in total

1.  Absorption and excretion of five tetracycline analogues in normal young men.

Authors:  N H Steigbigel; C W Reed; M Finland
Journal:  Am J Med Sci       Date:  1968-05       Impact factor: 2.378

2.  Some pharmacokinetic aspects of doxycycline metabolism in man.

Authors:  M Schach von Wittenau
Journal:  Chemotherapia (Basel)       Date:  1968

3.  [Kinetics of tetracyclines in human. II. Excretion, penetration into normal and inflammed tissues, behavior in a case of renal insufficiency and in hemodialysis].

Authors:  J Fabre; E Milek; P Kalfopoulos; G Mérier
Journal:  Schweiz Med Wochenschr       Date:  1971-05-08

4.  [Investigations on the determination of doxycycline concentrations in biological material by high pressure liquid chromatography and the agar diffusion method (author's transl)].

Authors:  R Böcker; A Weber
Journal:  Zentralbl Bakteriol A       Date:  1980

5.  The disposition of doxycycline by the rat.

Authors:  M Schach VON WITTENAU; M Schachaavonwittenau; T M Twomey; A C Swindell
Journal:  Chemotherapy       Date:  1972       Impact factor: 2.544

6.  [Tetracycline kinetics in man. Digestive absorption and serum concentration].

Authors:  J Fabre; E Milek; P Kalfopoulos; G Mérier
Journal:  Schweiz Med Wochenschr       Date:  1971-05-01

7.  The disposition of doxycyline by man and dog.

Authors:  M Schach von Wittenau; T M Twomey
Journal:  Chemotherapy       Date:  1971       Impact factor: 2.544

8.  [The pharmacokinetics of doxycycline in kidney insufficiency in geriatric patients compared to younger adults].

Authors:  C Simon; V Malerczyk; H Engelke; I Preuss; H Grahmann; K Schmidt
Journal:  Schweiz Med Wochenschr       Date:  1975-11-29

9.  Bioavailability of doxycycline monohydrate. A comparison with equivalent doses of doxycycline hydrochloride.

Authors:  A S Malmborg
Journal:  Chemotherapy       Date:  1984       Impact factor: 2.544

10.  Blood and organ concentrations of tetracycline and doxycycline in female mice. Comparison to males.

Authors:  R Böcker; L Warnke; C J Estler
Journal:  Arzneimittelforschung       Date:  1984
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  6 in total

Review 1.  Clinical pharmacokinetics of doxycycline and minocycline.

Authors:  S Saivin; G Houin
Journal:  Clin Pharmacokinet       Date:  1988-12       Impact factor: 6.447

2.  Statement on Older Travellers: Committee to Advise on Tropical Medicine and Travel.

Authors:  K L McClean
Journal:  Can Commun Dis Rep       Date:  2011-07-21

3.  Population Pharmacokinetic Model of Doxycycline Plasma Concentrations Using Pooled Study Data.

Authors:  Ashley M Hopkins; Jessica Wojciechowski; Ahmad Y Abuhelwa; Stuart Mudge; Richard N Upton; David J R Foster
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

Review 4.  Challenges of repurposing tetracyclines for the treatment of Alzheimer's and Parkinson's disease.

Authors:  Iva Markulin; Marija Matasin; Viktorija Erdeljic Turk; Melita Salković-Petrisic
Journal:  J Neural Transm (Vienna)       Date:  2022-01-04       Impact factor: 3.850

5.  Suppressive antibiotic therapy with oral tetracyclines for prosthetic joint infections: a retrospective study of 78 patients.

Authors:  M Pradier; O Robineau; A Boucher; M Titecat; N Blondiaux; M Valette; C Loïez; E Beltrand; S Nguyen; H Dézeque; H Migaud; Eric Senneville
Journal:  Infection       Date:  2017-10-20       Impact factor: 3.553

6.  Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes.

Authors:  María Valero-Muñoz; Richard M Wilson; Rosa Bretón-Romero; Dominique Croteau; David C Seldin; Flora Sam
Journal:  Int J Cardiol       Date:  2020-07-16       Impact factor: 4.039
  6 in total

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