Literature DB >> 3709618

Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone).

E Perucca, R Grimaldi, G Ruberto, C Gelmi, F Trimarchi, A Crema.   

Abstract

The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3709618     DOI： 10.1007/bf00615968

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  9 in total

1.  [EFFECT AND INDICATION OF A NEW ANTIEPILEPTIC DRUG].

Authors:  H PENIN
Journal:  Dtsch Med Wochenschr       Date:  1964-09-04       Impact factor: 0.628

2.  [THE MECHANISM OF ACTION OF L-1-CYCLOHEXYL-2-METHYLAMINOPROPAN-5,5-PHENYLETHYLBARBITURATE AND ITS SUITABILITY AS AN ANTIEPILEPTIC. COMPARATIVE STUDIES WITH PHENOBARBITAL].

Authors:  H HAAS
Journal:  Arzneimittelforschung       Date:  1963-08

3.  [CLINICAL COMMUNICATION ON THE THERAPY OF EPILEPSY WITH MALIASIN].

Authors:  H J KRUEGER; H SCHWARZ
Journal:  Med Welt       Date:  1965-04-03

4.  Observations on several cyclohexyland phenyl-alkylamines.

Authors:  E J FELLOWS; E MACKO; R A McLEAN
Journal:  J Pharmacol Exp Ther       Date:  1950-11       Impact factor: 4.030

5.  Rapid quantitative determination of underivatized carbamazepine, phenytoin, phenobarbital and p-hydroxyphenobarbital in biological fluids by packed column gas chromatography.

Authors:  R Riva; F Albani; A Baruzzi
Journal:  J Chromatogr       Date:  1980-11-14

6.  A comparison of the anticonvulsant properties of l-propylhexedrine, phenobarbital and a salt-like complex of l-propylhexedrine and phenobarbital in mice and rats.

Authors:  R W Dick; C L Mitchell
Journal:  Arch Int Pharmacodyn Ther       Date:  1967-12

7.  Disposition of sodium valproate in epileptic patients.

Authors:  E Perucca; G Gatti; G M Frigo; A Crema; S Calzetti; D Visintini
Journal:  Br J Clin Pharmacol       Date:  1978-06       Impact factor: 4.335

8.  Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse.

Authors:  H Iven; E Feldbusch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-09       Impact factor: 3.000

9.  [Barbexaclone in the treatment of the epilepsies (author's transl)].

Authors:  D Visintini; S Calzetti; D Mancia
Journal:  Riv Patol Nerv Ment       Date:  1981 Jan-Feb
  9 in total
  1 in total

1.  Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.

Authors:  P A Winstanley; C R Newton; G Pasvol; F J Kirkham; E Mberu; N Peshu; S A Ward; J B Were; D A Warrell; K Marsh
Journal:  Br J Clin Pharmacol       Date:  1992-02       Impact factor: 4.335
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.