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Literature DB >> 3709617

Reduced bioavailability and effect of furosemide given with food.

Abstract

10 healthy volunteers were given 40 mg furosemide p.o. with and without breakfast. The meal reduced the peak level of furosemide and decreased its bioavailability by approximately 30%. A heavy meal given to 5 of the subjects had no further effect. The reduced bioavailability caused a reduction in the diuretic effect.

Entities: Chemical

Mesh：

Substances：
Furosemide

Year: 1986 PMID： 3709617 DOI： 10.1007/bf00615967

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

4 in total

1. Gas chromatographic determination of furosemide in plasma using an extractive alkylation technique and an electron capture detector.

Authors: B Lindström; M Molander
Journal: J Chromatogr Date: 1974-12-04

2. Pharmacokinetics of orally administered furosemide.

Authors: M R Kelly; R E Cutler; A W Forrey; B M Kimpel
Journal: Clin Pharmacol Ther Date: 1974-02 Impact factor: 6.875

3. Pharmacokinetics of furosemide in man after intravenous and oral administration. Application of moment analysis.

Authors: M M Hammarlund; L K Paalzow; B Odlind
Journal: Eur J Clin Pharmacol Date: 1984 Impact factor: 2.953

4. Kinetics and dynamics of furosemide and slow-acting furosemide.

Authors: B Beermann
Journal: Clin Pharmacol Ther Date: 1982-11 Impact factor: 6.875

4 in total

12 in total

Review 1. Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications.

Authors: D Fleisher; C Li; Y Zhou; L H Pao; A Karim
Journal: Clin Pharmacokinet Date: 1999-03 Impact factor: 6.447

Review 2. Food-drug interactions.

Authors: Lars E Schmidt; Kim Dalhoff
Journal: Drugs Date: 2002 Impact factor: 9.546

10. Drug-drug interactions between sucroferric oxyhydroxide and losartan, furosemide, omeprazole, digoxin and warfarin in healthy subjects.

Authors: Edward Chong; Veena Kalia; Sandra Willsie; Peter Winkle
Journal: J Nephrol Date: 2014-04-04 Impact factor: 3.902

Reduced bioavailability and effect of furosemide given with food.

1. Gas chromatographic determination of furosemide in plasma using an extractive alkylation technique and an electron capture detector.

2. Pharmacokinetics of orally administered furosemide.

3. Pharmacokinetics of furosemide in man after intravenous and oral administration. Application of moment analysis.

4. Kinetics and dynamics of furosemide and slow-acting furosemide.

Review 1. Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications.

Review 2. Food-drug interactions.

3. Effect of activated charcoal on frusemide induced diuresis: a human class experiment for medical students.

4. Management of Cardio-Renal Syndrome and Diuretic Resistance.

Review 5. Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part II).

Review 6. Loop diuretic resistance complicating acute heart failure.

Review 7. Classic and Novel Mechanisms of Diuretic Resistance in Cardiorenal Syndrome.

8. Dilemmas in the Dosing of Heart Failure Drugs: Titrating Diuretics in Chronic Heart Failure.

Review 9. Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update.

10. Drug-drug interactions between sucroferric oxyhydroxide and losartan, furosemide, omeprazole, digoxin and warfarin in healthy subjects.