| Literature DB >> 3708330 |
Abstract
Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tissue was observed in SHRs of both sexes after 4 weeks of age, and was present in animals obtained from two different suppliers. In some SHRs, ventricle size was increased to 270% of control. Hence, it seems likely that some systemic and behavioral signs which are concomitant with hypertension in the SHR may be attributable to hydrocephalus and its neuropathological correlates.Entities:
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Year: 1986 PMID： 3708330 DOI： 10.1016/0006-8993(86)90488-9
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252