Literature DB >> 3708213

The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs.

M F Fitzgerald, S Moncada, L Parente.   

Abstract

The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lyso-platelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. Control guinea-pig lungs perfused either through the pulmonary circulation or through the airways and challenged with antigen did not release Paf-acether. Sensitized guinea-pig isolated lungs perfused through the pulmonary circulation and challenged with antigen released lyso-Paf but not Paf-acether. Sensitized guinea-pig isolated lungs perfused through the airways and challenged with antigen released three times more lyso-Paf and also Paf-acether. These results support a possible role for Paf-acether in respiratory anaphylaxis in the guinea-pig.

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Year:  1986        PMID： 3708213      PMCID： PMC1917123          DOI： 10.1111/j.1476-5381.1986.tb09481.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  21 in total

1.  Metabolism of prostacyclin. Oxidation by rhesus monkey lung 15-hydroxyl prostaglandin dehydrogenase.

Authors:  J C McGuire; F F Sun
Journal:  Arch Biochem Biophys       Date:  1978-07       Impact factor: 4.013

2.  Structural analysis of purified platelet-activating factor by lipases.

Authors:  J Benveniste; J P Le Couedic; J Polonsky; M Tence
Journal:  Nature       Date:  1977-09-08       Impact factor: 49.962

3.  Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

Authors:  P J Piper; J R Vane
Journal:  Nature       Date:  1969-07-05       Impact factor: 49.962

4.  Antigen-induced bronchial anaphylaxis in actively sensitized guinea-pigs. Pattern of response in relation to immunization regimen.

Authors:  P Andersson
Journal:  Allergy       Date:  1980-01       Impact factor: 13.146

5.  Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils.

Authors:  R N Pinckard; R S Farr; D J Hanahan
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

6.  IgE-induced release of a platelet-activating factor from rabbit lung.

Authors:  T C Kravis; P M Henson
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

7.  Recirculation of prostacyclin (PGI2) in the dog.

Authors:  G J Dusting; S Moncada; J R Vane
Journal:  Br J Pharmacol       Date:  1978-10       Impact factor: 8.739

8.  Platelet-activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes.

Authors:  J M Mencia-Huerta; J Benveniste
Journal:  Eur J Immunol       Date:  1979-05       Impact factor: 5.532

9.  Generation and release of platelet-activating factor (PAF) from enriched preparations of rabbit basophils; failure of human basophils to release PAF.

Authors:  S J Betz; G Z Lotner; P M Henson
Journal:  J Immunol       Date:  1980-12       Impact factor: 5.422

10.  The release of lyso-PAF from guinea-pig lungs.

Authors:  L Parente; M Fitzgerald; G De Nucci; S Moncada
Journal:  Eur J Pharmacol       Date:  1985-06-07       Impact factor: 4.432
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  12 in total

1.  Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 2. Effect on antigen-induced dual asthmatic response and infiltration of leukocytes into airways in actively sensitized conscious guinea pigs.

Authors:  T Sugasawa; N Imanishi; S Morooka
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

2.  Effect of nedocromil sodium on allergen-, PAF-, histamine- and bradykinin-induced airways vasodilatation and pulmonary obstruction in the pig.

Authors:  K Alving; R Matran; J M Lundberg
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

3.  Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs.

Authors:  S Sanjar; S Aoki; K Boubekeur; I D Chapman; D Smith; M A Kings; J Morley
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

4.  Blockade by methylation inhibitors of the anaphylactic response of guinea-pig lung strips.

Authors:  J Randon; J Lefort; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

5.  Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs.

Authors:  M Pretolani; J Lefort; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739

6.  Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea-pigs.

Authors:  L Daffonchio; I W Lees; A N Payne; B J Whittle
Journal:  Br J Pharmacol       Date:  1987-07       Impact factor: 8.739

Review 7.  PAF antagonists. Their potential therapeutic role in asthma.

Authors:  K F Chung; P J Barnes
Journal:  Drugs       Date:  1988-02       Impact factor: 9.546

8.  Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists.

Authors:  P J Piper; A G Stewart
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739

9.  Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine.

Authors:  S Morooka; M Uchida; N Imanishi
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

10.  Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2.

Authors:  D M Conroy; P Sirois
Journal:  Inflammation       Date:  1999-10       Impact factor: 4.092
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