Literature DB >> 3708002

Iron mobilisation from lactoferrin by chelators at physiological pH.

G J Kontoghiorghes.   

Abstract

Several alpha-ketohydroxypyridine, 2-hydroxypyridine N-oxide and 8-hydroxyquinoline chelators were shown to mobilise iron from diferric 59Fe-labelled human lactoferrin at physiological pH without the use of mediators or reducing agents. 1,2-Dimethyl-3-hydroxypyrid-4-one was found to be the most effective chelator, removing 90% of 59Fe from [59Fe]lactoferrin, in contrast to desferrioxamine, which was ineffective under the same conditions.

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Year:  1986        PMID： 3708002     DOI： 10.1016/0304-4165(86)90164-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  New developments and controversies in iron metabolism and iron chelation therapy.

Authors:  Christina N Kontoghiorghe; George J Kontoghiorghes
Journal:  World J Methodol       Date:  2016-03-26

2.  Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients.

Authors:  N Ahmadzadeh; M Shingu; M Nobunaga
Journal:  Clin Rheumatol       Date:  1989-09       Impact factor: 2.980

Review 3.  Present status and future prospects of oral iron chelation therapy in thalassaemia and other diseases.

Authors:  G J Kontoghiorghes
Journal:  Indian J Pediatr       Date:  1993 Jul-Aug       Impact factor: 1.967

Review 4.  Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine.

Authors:  George J Kontoghiorghes; Katia Neocleous; Annita Kolnagou
Journal:  Drug Saf       Date:  2003       Impact factor: 5.606

5.  Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one.

Authors:  G J Kontoghiorghes; M A Aldouri; A V Hoffbrand; J Barr; B Wonke; T Kourouclaris; L Sheppard
Journal:  Br Med J (Clin Res Ed)       Date:  1987-12-12

6.  Structure and domain dynamics of human lactoferrin in solution and the influence of Fe(III)-ion ligand binding.

Authors:  Clemens Sill; Ralf Biehl; Bernd Hoffmann; Aurel Radulescu; Marie-Sousai Appavou; Bela Farago; Rudolf Merkel; Dieter Richter
Journal:  BMC Biophys       Date:  2016-11-04       Impact factor: 4.778

Review 7.  Drug antioxidant effects. A basis for drug selection?

Authors:  B Halliwell
Journal:  Drugs       Date:  1991-10       Impact factor: 9.546

Review 8.  Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine.

Authors:  Viktor A Timoshnikov; Olga Yu Selyutina; Nikolay E Polyakov; Victoria Didichenko; George J Kontoghiorghes
Journal:  Int J Mol Sci       Date:  2022-01-23       Impact factor: 5.923

Review 9.  New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications.

Authors:  George J Kontoghiorghes; Annita Kolnagou; Theodora Demetriou; Marina Neocleous; Christina N Kontoghiorghe
Journal:  Int J Mol Sci       Date:  2021-05-24       Impact factor: 5.923

Review 10.  Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases.

Authors:  George J Kontoghiorghes; Christina N Kontoghiorghe
Journal:  Cells       Date:  2020-06-12       Impact factor: 6.600
  10 in total

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