| Literature DB >> 3707658 |
W Buijs, B van Meeteren-Wälchli, D D Breimer, A van der Gen.
Abstract
A partly new synthesis of 3-hydroxymethylantipyrine, an important metabolite of antipyrine in man and therefore frequently used as a reference substance, is described. The use of tri-n-butyltin hydride to reduce the vinyl bromide system in 3-hydroxymethyl-4-bromoantipyrine is the main improvement, since it enables the isolation of salt-free 3-hydroxymethylantipyrine in an almost quantitative yield.Entities:
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Year: 1986 PMID： 3707658
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172