Literature DB >> 3707572

Stereochemical difference between 12-hydroxy-5,8,10,14-eicosatetraenoic acid in platelets and psoriatic lesions.

P M Woollard.   

Abstract

Stereochemical analysis of 12-hydroxy-5,8,10,14-eicosatetraenoic acid derived from the lesional scale of patients with psoriasis is reported. Resolution of the C-12 hydroxyl enantiomers was carried out by high pressure liquid chromatography of their diastereomeric methyl ester dehydroabietyl urethane derivatives. The 'psoriasis derived" compound was shown to be stereochemically distinct from the platelet 12(S)-enantiomer as its derivative co-chromatographed with the 12(R)-diastereomer.

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Year:  1986        PMID： 3707572     DOI： 10.1016/0006-291x(86)90891-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  20 in total

1.  12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea.

Authors:  M L Schwartzman; M Balazy; J Masferrer; N G Abraham; J C McGiff; R C Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

Review 2.  The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.

Authors:  Agustí Muñoz-Garcia; Christopher P Thomas; Diane S Keeney; Yuxiang Zheng; Alan R Brash
Journal:  Biochim Biophys Acta       Date:  2013-09-07

3.  Heterogeneous distribution of lipoxygenase products in psoriatic skin lesions.

Authors:  K Fogh; J Kiil; T Herlin; T Ternowitz; K Kragballe
Journal:  Arch Dermatol Res       Date:  1987       Impact factor: 3.017

4.  Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of a 12R-LOX-chaperone complex.

Authors:  Gouri Deb; Karen Boeshanes; William K Idler; Bijan Ahvazi
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-07-19

Review 5.  Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition.

Authors:  Mariko Nakano; Catherine M Lockhart; Edward J Kelly; Allan E Rettie
Journal:  Drug Metab Rev       Date:  2014-05-26       Impact factor: 4.518

6.  Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.

Authors:  Zheyong Yu; Claus Schneider; William E Boeglin; Alan R Brash
Journal:  Arch Biochem Biophys       Date:  2006-09-25       Impact factor: 4.013

7.  Discovery of a second 15S-lipoxygenase in humans.

Authors:  A R Brash; W E Boeglin; M S Chang
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

8.  Psoriatic skin lesions contain a novel lipid neutrophil chemokinetic compound which is distinct from known chemoattractant eicosanoids.

Authors:  R D Camp; F M Cunningham; N J Fincham; M W Greaves; A Kobza Black; A I Mallet; P M Woollard
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739

9.  12-Hydroxyeicosatetraenoic acid (12-HETE) is a chemotactic stimulus for epidermal cells.

Authors:  R Hein; E Gross; T Ruzicka; T Krieg
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

10.  A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.

Authors:  W E Boeglin; R B Kim; A R Brash
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205
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