Literature DB >> 370687

Effects of valproate and ethosuximide on thalamocortical excitability.

W J Nowack, R N Johnson, R N Englander, G R Hanna.   

Abstract

Sodium valproate and ethosuximide are anticonvulsants employed in the treatment of petit mal epilepsy; both drugs are considered to be thalamically active. Valproate and ethosuximide both decreased the average evoked response following the second of two stimuli delivered to the ventrolateral thalamus at stimulus frequencies in the region of 3 Hz. Ethosuximide, but not valproate, enhanced the average evoked response at high stimulus frequencies an action shared with several convulsant treatments having different modes of action. The clinical effects of valproate and ethosuximide can be related to this differential modulation of thalamocortical excitability.

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Year:  1979        PMID： 370687     DOI： 10.1212/wnl.29.1.96

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  5 in total

1.  Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy.

Authors:  David Sherman; Ning Zhang; Shikha Garg; Nitish V Thakor; Marek A Mirski; Mirinda Anderson White; Melvin J Hinich
Journal:  Int J Neural Syst       Date:  2011-04       Impact factor: 5.866

2.  Analysis of epileptic activity in a system of interconnected neurons. A biological criticality theory.

Authors:  G C Theodoridis; J D Charlton; W J Nowack; R N Johnson
Journal:  Ann Biomed Eng       Date:  1980       Impact factor: 3.934

Review 3.  Mechanisms of anticonvulsant drug action. II. Drugs primarily used for absence epilepsy.

Authors:  C L Faingold; R A Browning
Journal:  Eur J Pediatr       Date:  1987-01       Impact factor: 3.183

Review 4.  The thalamocortical contribution to epilepsy.

Authors:  W J Nowack; G C Theodoridis
Journal:  Bull Math Biol       Date:  1991       Impact factor: 1.758

Review 5.  Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity.

Authors:  Timo T Myöhänen; J Arturo García-Horsman; Jofre Tenorio-Laranga; Pekka T Männistö
Journal:  J Histochem Cytochem       Date:  2009-05-26       Impact factor: 2.479
  5 in total

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